DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC11 and Hdac4

DIOPT Version :9

Sequence 1:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_008765500.1	Gene:	Hdac4 / 363287	RGDID:	619979	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	75/360 - (20%)
Similarity:	129/360 - (35%)	Gaps:	105/360 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HHEEQESEEVVWVKRDDARSAGKLPIVFSRNYAVRFGGLERLHPFDAAKGKHIHKLLCAQLQLDD 73
            |.|.....:.:|.:..:....||...:..|...:.  .|:.:|       ...|.||
  Rat   687 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLE--ELQTVH-------SEAHTLL-------- 734

  Fly    74 GSFYEPTELTKDQLRRIHTREYLKSLR------------------WS---------MNVACIAEV 111
               |....|.:   :::.:::.|.||.                  |:         :.|.|:.|:
  Rat   735 ---YGTNPLNR---QKLDSKKLLGSLTSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVEL 793

  Fly   112 PLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLALDYGWAINLGGGFHHCCSYRGGGFCPYADISL 176
            ..                       .:..|:  |..|:|:....| ||.......|||.:..:::
  Rat   794 VF-----------------------KVATGE--LKNGFAVVRPPG-HHAEESTPMGFCYFNSVAI 832

  Fly   177 LIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNN-----VAAVYIFDMYNAFVYPRDHVAKE-- 234
            ....|  |:...|.:|:|||.|.|.|||.::.|.|     ..:::.:|..|.|  |......|
  Rat   833 AAKLL--QQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFF--PGSGAPDEVG 893

  Fly   235 -------SIRCAVE--LRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEG--DPLGNL 288
                   ::..|..  |.....|..||...:..:|....||.||:|:.::|.|.:||  .|||..
  Rat   894 TGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIANEFAPDVVLVSSGFDAVEGHPTPLGGY 958

  Fly   289 AISAE--GVIERDRLVFSTFRALGIPVVMLLSGGY 321
            .:||:  |.:.:..:..:     |..:|:.|.||:
  Rat   959 NLSAKCFGYLTKQLMGLA-----GGRIVLALEGGH 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	68/318 (21%)
Hdac4	XP_008765500.1	ClassIIa_HDAC4_Gln-rich-N	<99..160	CDD:197398
Hdac4	XP_008765500.1	HDAC4	661..1069	CDD:212530	75/360 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900