DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC11 and hdac10

DIOPT Version :9

Sequence 1:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_021326130.1	Gene:	hdac10 / 327253	ZFINID:	ZDB-GENE-030131-5464	Length:	723	Species:	Danio rerio

Alignment Length:	304	Identity:	73/304 - (24%)
Similarity:	125/304 - (41%)	Gaps:	68/304 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ELTKDQLRRIHTREYLKSLRWS--MNVACIAEVPLMAF---VPNRYIQRSYLRPMRFQAAGSIL- 139
            :.|:.::...|:.|||::::.:  |||.     .||||   ..:.|..::.....:. |||:.|
Zfish   104 QATEQEILLAHSEEYLEAVKQTPGMNVE-----ELMAFSKKYNDVYFHQNIYHCAKL-AAGATLQ 162

  Fly   140 ----AGKLALDYGWAINLGGGFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAH 200
                ..|..:..|.|:....| ||.......|||.:.:::  |..|:.::.:.:.||:|||.|.|
Zfish   163 LVDSVMKREVRNGMALVRPPG-HHSQRSAANGFCVFNNVA--IAALYAKKNYNLNRILIVDWDVH 224

  Fly   201 QGNGHERDFNNVAAVYIFDMYNAFVYPRDHVAKESIRCAVELRNYTE------DGF--------- 250
            .|.|.:..|....:|..|..:.     .:|   :|....:...:|:.      .||
Zfish   225 HGQGIQYCFEEDPSVLYFSWHR-----YEH---QSFWPNLPESDYSSVGKGKGSGFNINLPWNKV 281

  Fly   251 ------YLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEGDPLGNLAISAEGVIERDRLVFSTFRAL 309
                  ||......|:....||.|::|:.:||.|...|||.|.:....|        :|:....|
Zfish   282 GMTNSDYLAAFFHVLLPVAYEFDPELVIVSAGFDSAIGDPEGEMCALPE--------IFAHLTHL 338

  Fly   310 GIPVV-----MLLSGGYLKASAG-VITDSIVNL------RLQGL 341
            .:|:.     ::|.|||...|.| .:..::.:|      |:.||
Zfish   339 LMPLAAGKMCVVLEGGYNLTSLGQSVCQTVHSLLGDPTPRISGL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	69/291 (24%)
hdac10	XP_021326130.1	HDAC10	68..404	CDD:212546	73/304 (24%)
hdac10	XP_021326130.1	Arginase_HDAC	<607..717	CDD:327367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900