Protein Alignment HDAC11 and HDAC2

DIOPT Version :10

• Sequence 1: NP_733048.1
• Gene: HDAC11 / 326120
• FlyBaseID: FBgn0051119
• Length: 343
• Species: Drosophila melanogaster
• Sequence 2: NP_001518.3
• Gene: HDAC2 / 3066
• HGNCID: 4853
• Length: 488
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 81/309 - (26%)
• Similarity: 127/309 - (41%)
• Gaps: 71/309 - (22%)

  Fly    51 HPFDAAKGKHIHKLLCAQLQLDDGSF-----YEPTELTKDQLRRIHTREYLKSLRWSMNVACIAE 110
            ||....:.:..|.||     |:.|.:     |.|.:.|.:::.:.|:.||:|.||
Human    29 HPMKPHRIRMTHNLL-----LNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLR---------- 78

  Fly   111 VPLMAFVPNRYIQRSYLRPM-RFQ-----------------AAGSILAGKLALD---YGWAINLG 154
                :..|:.  ...|.:.| ||.                 :.|..:||.:.|:   ...|:|..
Human    79 ----SIRPDN--MSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWA 137

  Fly   155 GGFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYI-- 217
            ||.||.......|||...||.|.|:.|.:..    :|::.:|:|.|.|:|.|..|.....|..
Human   138 GGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGVEEAFYTTDRVMTVS 198

  Fly   218 FDMYNAFVYP-----RDHVAKESIRCAVE--LRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNA 275
            |..|..: :|     ||..|.:....||.  :|:..:|..|.:..|..:.:.:..::|..||...
Human   199 FHKYGEY-FPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQC 262

  Fly   276 GTDVLEGDPLGNLAISAEG---VIERDRLVFSTFRALGIPVVMLLSGGY 321
            |.|.|.||.||...::.:|   .:|    |..||   .:|::||..|||
Human   263 GADSLSGDRLGCFNLTVKGHAKCVE----VVKTF---NLPLLMLGGGGY 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_733048.1	HDAC_classIV	51..336	CDD:212519	81/309 (26%)
HDAC2	NP_001518.3	HDAC2	9..374	CDD:212535	81/309 (26%)
		Histone deacetylase	9..322		81/309 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..488