DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC11 and Hdac6

DIOPT Version :9

Sequence 1:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001123888.1	Gene:	Hdac6 / 15185	MGIID:	1333752	Length:	1149	Species:	Mus musculus

Alignment Length:	390	Identity:	90/390 - (23%)
Similarity:	149/390 - (38%)	Gaps:	97/390 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRLTERVHHEEQESEEVVWVKRDDARSAGKLPI----VFSRNYAVRFGGLERLHPFDAAKGKHI 61
            ||:|:     :..|.:.||.::..|.....::|:    ||.          |:|:.|..
Mouse    55 MKKLS-----QPAEEDLVVGLQGLDLNPETRVPVGTGLVFD----------EQLNDFHC------ 98

  Fly    62 HKLLCAQLQLDDGSFYEPTE-------------------------LTKDQLRRIHTREYLKSLRW 101
                     |.|.||.|..|                         ..|::|..:|:.||:..:..
Mouse    99 ---------LWDDSFPESPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMET 154

  Fly   102 S--MNVACIAEVPLMAFVPNRYIQRSYLRPMRFQ----AAGSILAGKLAL-----DYGWAINLGG 155
            :  ||.   .|:.::|    ......||.|..:.    |.||:|....||     ..|.|:....
Mouse   155 TQYMNE---GELRVLA----ETYDSVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPP 212

  Fly   156 GFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYIFDM 220
            | ||.......|:|.:.  .|.:...:.|:..|::|::|||.|.|.|.|.:..|:...:|..|.:
Mouse   213 G-HHAQHNLMDGYCMFN--HLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSI 274

  Fly   221 Y---NAFVYPRDHVAKESIRCAVELRNYT----------EDGFYLRQLKRCLMQSLAEFRPDMVV 272
            :   :...:|....:..|.....:.:.||          .|..|:......|:...:||:|.:|:
Mouse   275 HRYEHGRFWPHLKASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVL 339

  Fly   273 YNAGTDVLEGDPLGNLAISAEGVIERDRLVFSTFRALGIPVVMLLSGGY-LKASAGVITDSIVNL 336
            ..||.|.|.|||.|.:|.:..|......|:..   ..|..:::.|.||| |:|.|..::.|:..|
Mouse   340 VAAGFDALHGDPKGEMAATPAGFAHLTHLLMG---LAGGKLILSLEGGYNLRALAKGVSASLHTL 401

Fly 337 336
Mouse 402 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	77/334 (23%)
Hdac6	NP_001123888.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61		3/10 (30%)
		Histone deacetylase 1	87..403		82/353 (23%)
		Arginase_HDAC	98..434	CDD:418394	77/332 (23%)
		Histone deacetylase 2	481..799
		HDAC6-dom2	484..834	CDD:212527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	954..975
		zf-UBP	1067..1129	CDD:396634
		Ubiquitin binding. /evidence=ECO:0000250\|UniProtKB:Q9UBN7	1088..1090
		Ubiquitin binding. /evidence=ECO:0000250\|UniProtKB:Q9UBN7	1116..1123
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810