DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC11 and Hdac3

DIOPT Version :9

Sequence 1:NP_001247296.1 Gene:HDAC11 / 326120 FlyBaseID:FBgn0051119 Length:343 Species:Drosophila melanogaster
Sequence 2:NP_034541.2 Gene:Hdac3 / 15183 MGIID:1343091 Length:428 Species:Mus musculus


Alignment Length:310 Identity:83/310 - (26%)
Similarity:126/310 - (40%) Gaps:72/310 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 HPFDAAKGKHIHKL-LCAQLQLDDGSF-----YEPTELTKDQLRRIHTREYL------------- 96
            ||...      |:| |...|.|..|.:     ::|.:.::..:.|.|:.:|:             
Mouse    22 HPMKP------HRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQG 80

  Fly    97 --KSLRWSMNVA--CIAEVPLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLALD---YGWAINLG 154
              |||. :.||.  |.....|..|. :||             .|:.|.|...|:   ...|||..
Mouse    81 FTKSLN-AFNVGDDCPVFPGLFEFC-SRY-------------TGASLQGATQLNNKICDIAINWA 130

  Fly   155 GGFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDF---NNVAAVY 216
            ||.||...:...|||...||.:.|:.|.:..|    |::.:|:|.|.|:|.:..|   :.|..| 
Mouse   131 GGLHHAKKFEASGFCYVNDIVIGILELLKYHP----RVLYIDIDIHHGDGVQEAFYLTDRVMTV- 190

  Fly   217 IFDMYNAFVYPRD----HVAKESIR--CA-VELRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYN 274
            .|..|..:.:|..    .|..||.|  |. |.||:..:|..|....:..:.|.:..::|..:|..
Mouse   191 SFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQ 255

  Fly   275 AGTDVLEGDPLG--NLAISAEG-VIERDRLVFSTFRALGIPVVMLLSGGY 321
            .|.|.|..|.||  ||:|...| .:|       ..::..||:::|..|||
Mouse   256 CGADSLGCDRLGCFNLSIRGHGECVE-------YVKSFNIPLLVLGGGGY 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC11NP_001247296.1 HDAC_classIV 51..336 CDD:212519 83/310 (27%)
Hdac3NP_034541.2 HDAC3 3..383 CDD:212529 83/310 (27%)
Histone deacetylase 3..316 83/310 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 387..424
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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