Protein Alignment HDAC11 and HDAC5

DIOPT Version :9

• Sequence 1: NP_001247296.1
• Gene: HDAC11 / 326120
• FlyBaseID: FBgn0051119
• Length: 343
• Species: Drosophila melanogaster
• Sequence 2: XP_016879477.1
• Gene: HDAC5 / 10014
• HGNCID: 14068
• Length: 1161
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 85/383 - (22%)
• Similarity: 151/383 - (39%)
• Gaps: 104/383 - (27%)

  Fly     8 VHHEEQESEEVVWVKRDDA-------RSAGK------LPIVFSRNYAVRFG--GLERLHPFDAAK 57
            ||.|.....:.:|.:..:.       |..|:      :..|.|..:.:.:|  .|.| ...|:.|
Human   742 VHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNR-QKLDSKK 805

  Fly    58 -----GKHIHKLL-CAQLQLDDGSFYEPTELTKDQLRRIHTREYLKSLRWSMNVACIAEVPLMAF 116
                 .:.::.:| |..:.:|..:.:          ..:|:...::     |.|.|:.|   :||
Human   806 LLGPISQKMYAVLPCGGIGVDSDTVW----------NEMHSSSAVR-----MAVGCLLE---LAF 852

  Fly   117 VPNRYIQRSYLRPMRFQAAGSILAGKLALDYGWAINLGGGFHHCCSYRGGGFCPYADISLLIVRL 181
                                .:.||:  |..|:||....| ||.......|||.:..:::....|
Human   853 --------------------KVAAGE--LKNGFAIIRPPG-HHAEESTAMGFCFFNSVAITAKLL 894

  Fly   182 FEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYIFDMY---NAFVYPRDHVAKE--------- 234
              |:...|.:::|||.|.|.|||.::.|.|..:|....::   |...:|.....:|
Human   895 --QQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGY 957

  Fly   235 SIRCAVELRNYT-------EDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEG--DPLGNLAI 290
            ::..|     :|       .|..||...:..:|....||.||:|:.:||.|.:||  .|||..::
Human   958 NVNVA-----WTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSV 1017

  Fly   291 SAE--GVIERDRLVFSTFRALGIPVVMLLSGGY-----LKASAGVITDSIVNLRLQGL 341
            :|.  |.:.|..:..:     |..||:.|.||:     ..||...:: :::::.||.|
Human  1018 TARCFGHLTRQLMTLA-----GGRVVLALEGGHDLTAICDASEACVS-ALLSVELQPL 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	71/318 (22%)
HDAC5	XP_016879477.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810