DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB11 and Anxa6

DIOPT Version :9

Sequence 1:	NP_001259616.1	Gene:	AnxB11 / 32612	FlyBaseID:	FBgn0030749	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_077070.2	Gene:	Anxa6 / 79125	RGDID:	621172	Length:	673	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	141/307 - (45%)
Similarity:	205/307 - (66%)	Gaps:	4/307 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 ANFDAVKDAHDLRKAMKGFGTDEDALINIICRRSNEQRQEIQRQFKTHFGKDLIEDIKSETSGNF 266
            |:|||.:||..|..||||||:|:::::.:|..|||:|||||.:.:|:.:|||||.|:|.|.:|.|
  Rat    18 ADFDANQDAEALYTAMKGFGSDKESILELITSRSNKQRQEICQSYKSLYGKDLIADLKYELTGKF 82

  Fly   267 EKLLVGLLRPIVDYYC--AELNDAMAGLGTDEEVLIEILCTLSNMEINTIKNQYLRLYGAHLESE 329
            |:|:|.|:||:.  ||  .|:.||::|:||||:.|||||.:.:|.:|:.:...|...|...|||:
  Rat    83 ERLIVNLMRPLA--YCDAKEIKDAISGIGTDEKCLIEILASRTNEQIHQLVAAYKDAYERDLESD 145

  Fly   330 LKSETSGNFKRLLTSLCTAARDESGRVDPVAAKNDARELLKAGELRVGTDESMFNMILCQRNYQQ 394
            :..:|||:|:::|..|....|:....|.....:.|.::|.:||||:.||||:.|..||..|:.|.
  Rat   146 IIGDTSGHFQKMLVVLLQGTRENDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQH 210

  Fly   395 LKLIFQEYEGMTGHSLEKAIKKEFSGDVMEGLIAIYRCVTNKAEYFASRLHKAMAGIGTNDTQLI 459
            |:|:|.||...||..:|.:|:.|.|||..:.::|:.:|:.:..||||.||.|||.|:||.|..||
  Rat   211 LRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLI 275

  Fly   460 RVIITRSEIDMTDIKVAFERLYGKSLKSWIKGDTSGHYKHALYALVG 506
            |::::|||:||.||:..|...|.|||.|.||.||||.||.||..|.|
  Rat   276 RIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKALLKLCG 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB11	NP_001259616.1	Annexin	209..273	CDD:278615	33/63 (52%)
		Annexin	280..345	CDD:278615	27/66 (41%)
		Annexin	364..429	CDD:278615	28/64 (44%)
		Annexin	439..504	CDD:278615	38/64 (59%)
Anxa6	NP_077070.2	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	20..91		37/70 (53%)
		Annexin	24..89	CDD:278615	33/64 (52%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	92..163		29/72 (40%)
		Annexin	97..161	CDD:278615	25/63 (40%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	175..247		29/71 (41%)
		Annexin	179..245	CDD:278615	28/65 (43%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	251..322		40/70 (57%)
		Annexin	255..320	CDD:278615	38/64 (59%)
		Annexin 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	363..434
		Annexin	368..432	CDD:278615
		Annexin 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	435..506
		Annexin	439..504	CDD:278615
		Annexin 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	521..595
		Annexin	527..593	CDD:278615
		Annexin 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	599..670
		Annexin	603..668	CDD:278615
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750