DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB11 and ANXA11

DIOPT Version :9

Sequence 1:	NP_001259616.1	Gene:	AnxB11 / 32612	FlyBaseID:	FBgn0030749	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_005269798.1	Gene:	ANXA11 / 311	HGNCID:	535	Length:	605	Species:	Homo sapiens

Alignment Length:	511	Identity:	203/511 - (39%)
Similarity:	265/511 - (51%)	Gaps:	84/511 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GSGMPSHPPTSTNHHEPPRAPFGAGWVPPMQQNSP----YPPPSQPHPHSQPSSQMHPQQHQQYP 65
            |:.||:..|.:.....||..|.|.|..|..||..|    ||||....|...||       :..||
Human   167 GANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPS-------YPPYP 224

  Fly    66 GGAPAPYPPMSAP---YPSAAPSYPP--YPTSNPYPAQYAPPAHNHYQQPSVSNSPYPADRGYTP 125
             |||.|..||..|   .|.|.|..||  ||...|.|.    |..   |||..|...||.....||
Human   225 -GAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPL----PGQ---QQPVPSYPGYPGSGTVTP 281

  Fly   126 AMTAGYDAGYGYGNGQGHGQGHGHGQGHGHGHGQGHEYGHGYGQGYGHGQGHGNGQGHAHRSLPA 190
            |:.                                                            |.
Human   282 AVP------------------------------------------------------------PT 286

  Fly   191 HREGTPTVVPAANFDAVKDAHDLRKAMKGFGTDEDALINIICRRSNEQRQEIQRQFKTHFGKDLI 255
            ......|:..|..||.::||..||||||||||||.|:|:.:..|||:|||:|...|||.:|||||
Human   287 QFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLI 351

  Fly   256 EDIKSETSGNFEKLLVGLLRPIVDYYCAELNDAMAGLGTDEEVLIEILCTLSNMEINTIKNQYLR 320
            :|:|||.||||||.::.|::..|.:...|:.:|:.|:||||..|||||.:.||..|..:...|..
Human   352 KDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKA 416

  Fly   321 LYGAHLESELKSETSGNFKRLLTSLCTAARDESGRVDPVAAKNDARELLKAGELRVGTDESMFNM 385
            .:...||..::|:|||:|:|||.||....||||..||...|:.||:||..|||.|:|||||.||.
Human   417 EFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRDAQELYAAGENRLGTDESKFNA 481

  Fly   386 ILCQRNYQQLKLIFQEYEGMTGHSLEKAIKKEFSGDVMEGLIAIYRCVTNKAEYFASRLHKAMAG 450
            :||.|:...|..:|.||:.|||..:||:|.:|.|||:.||::|:.:|:.|...:||.||:|||.|
Human   482 VLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRG 546

  Fly   451 IGTNDTQLIRVIITRSEIDMTDIKVAFERLYGKSLKSWIKGDTSGHYKHALYALVG 506
            .||.|..|||::::|||.|:.||:..::|:|||||...|.|||||.|:..|..:.|
Human   547 AGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTSGDYRKILLKICG 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB11	NP_001259616.1	Annexin	209..273	CDD:278615	41/63 (65%)
		Annexin	280..345	CDD:278615	26/64 (41%)
		Annexin	364..429	CDD:278615	34/64 (53%)
		Annexin	439..504	CDD:278615	34/64 (53%)
ANXA11	XP_005269798.1	Annexin	304..369	CDD:278615	41/64 (64%)
		Annexin	376..441	CDD:278615	26/64 (41%)
		Annexin	459..525	CDD:278615	34/65 (52%)
		Annexin	535..600	CDD:278615	34/64 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141918
Domainoid	1	1.000	77	1.000	Domainoid score	I8894
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2403
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	1	1.000	-	-		mtm8618
orthoMCL	1	0.900	-	-		OOG6_100522
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4028
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.740