DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB11 and ANXA5

DIOPT Version :9

Sequence 1:	NP_001259616.1	Gene:	AnxB11 / 32612	FlyBaseID:	FBgn0030749	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001145.1	Gene:	ANXA5 / 308	HGNCID:	543	Length:	320	Species:	Homo sapiens

Alignment Length:	314	Identity:	138/314 - (43%)
Similarity:	198/314 - (63%)	Gaps:	2/314 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 GTPTVVPAANFDAVKDAHDLRKAMKGFGTDEDALINIICRRSNEQRQEIQRQFKTHFGKDLIEDI 258
            ||.|..|  .||...||..|||||||.||||::::.::..|||.|||||...|||.||:||::|:
Human     7 GTVTDFP--GFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDL 69

  Fly   259 KSETSGNFEKLLVGLLRPIVDYYCAELNDAMAGLGTDEEVLIEILCTLSNMEINTIKNQYLRLYG 323
            |||.:|.||||:|.|::|...|...||..|:.|.||:|:||.||:.:.:..|:..||..|...||
Human    70 KSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYG 134

  Fly   324 AHLESELKSETSGNFKRLLTSLCTAARDESGRVDPVAAKNDARELLKAGELRVGTDESMFNMILC 388
            :.||.::..:|||.::|:|..|..|.||....:|....:.||:.|.:||||:.||||..|..|..
Human   135 SSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFG 199

  Fly   389 QRNYQQLKLIFQEYEGMTGHSLEKAIKKEFSGDVMEGLIAIYRCVTNKAEYFASRLHKAMAGIGT 453
            .|:...|:.:|.:|..::|..:|:.|.:|.||::.:.|:|:.:.:.:...|.|..|:.||.|.||
Human   200 TRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGT 264

  Fly   454 NDTQLIRVIITRSEIDMTDIKVAFERLYGKSLKSWIKGDTSGHYKHALYALVGE 507
            :|..||||:::|||||:.:|:..|.:.:..||.|.|||||||.||.||..|.||
Human   265 DDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGE 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB11	NP_001259616.1	Annexin	209..273	CDD:278615	38/63 (60%)
		Annexin	280..345	CDD:278615	25/64 (39%)
		Annexin	364..429	CDD:278615	24/64 (38%)
		Annexin	439..504	CDD:278615	34/64 (53%)
ANXA5	NP_001145.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	15..86		41/70 (59%)
		Annexin	20..84	CDD:395139	38/63 (60%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	87..158		27/70 (39%)
		Annexin	91..156	CDD:395139	25/64 (39%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	170..242		25/71 (35%)
		Annexin	174..240	CDD:395139	24/65 (37%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	246..317		35/70 (50%)
		Annexin	250..315	CDD:395139	34/64 (53%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000305\|PubMed:25417112	314..319		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141920
Domainoid	1	1.000	86	1.000	Domainoid score	I8083
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760