DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB11 and Anxa7

DIOPT Version :9

Sequence 1:	NP_001259616.1	Gene:	AnxB11 / 32612	FlyBaseID:	FBgn0030749	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006251686.2	Gene:	Anxa7 / 155423	RGDID:	621173	Length:	485	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	203/495 - (41%)
Similarity:	273/495 - (55%)	Gaps:	63/495 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YPGGAPAPYPPMSAPYPSAAPSYPP------YPTSN--PYPAQYAPPAHNHYQQPSVSNSPYPAD 120
            |||..|..|||.        |.|||      :|||.  |||:.:.|.....|  |...:..||..
  Rat     3 YPGYPPTGYPPF--------PGYPPAGQESSFPTSGQYPYPSGFPPMGGGAY--PPAPSGGYPGA 57

  Fly   121 RGYTPAMTAGYDA--GY----------GYGNGQGHGQGHGHGQGHGHGHGQGHEYGHGYGQ---- 169
            .|| |: ..||.|  ||          .|..|||.|...|.....|:.......||.|..|
  Rat    58 GGY-PS-PGGYPAPGGYPGTLNPGGPPSYPGGQGFGAPPGGAGFSGYPQPPAQSYGGGPAQVPVP 120

  Fly   170 -GYGHGQ---GHGNGQG--------HAHRSLPAH--------------REGTP-TVVPAANFDAV 207
             |:..||   .:..||.        .:..|.||.              .:||. |:.||:||||:
  Rat   121 GGFPGGQMPSQYPGGQSPYPGQIDTESFSSYPAFSPVSLDYSSDPAAMTQGTQGTIRPASNFDAM 185

  Fly   208 KDAHDLRKAMKGFGTDEDALINIICRRSNEQRQEIQRQFKTHFGKDLIEDIKSETSGNFEKLLVG 272
            :||..||||||||||||.|:::::..|||:|||:|:..|||.:|||||:|:|||.|||.|:|::.
  Rat   186 RDAEILRKAMKGFGTDEQAIVDVVSNRSNDQRQQIKAAFKTMYGKDLIKDLKSELSGNMEELILA 250

  Fly   273 LLRPIVDYYCAELNDAMAGLGTDEEVLIEILCTLSNMEINTIKNQYLRLYGAHLESELKSETSGN 337
            |..|...|....|..|:.|.||.|.||||||||.:|.||..|...|...:|..||.:::|:|||:
  Rat   251 LFMPPTYYDAWSLRKAIQGAGTQERVLIEILCTRTNQEIRDIVRCYQLEFGRELERDIRSDTSGH 315

  Fly   338 FKRLLTSLCTAARDESGRVDPVAAKNDARELLKAGELRVGTDESMFNMILCQRNYQQLKLIFQEY 402
            |:|||.|:|...||||..::...|:.||:.|.:|||.|:|||||.|||||..|::.||:...:.|
  Rat   316 FERLLVSMCQGNRDESPSINHQMAQEDAQRLYQAGEGRLGTDESCFNMILATRSFPQLRATMEAY 380

  Fly   403 EGMTGHSLEKAIKKEFSGDVMEGLIAIYRCVTNKAEYFASRLHKAMAGIGTNDTQLIRVIITRSE 467
            ..|....|..::.:||||.|..||..|.:|..|:..:||.||:.:|.|.||:|:.|:|:::||||
  Rat   381 SRMANRDLLSSVSREFSGYVESGLKTILQCALNRPAFFAERLYYSMKGAGTDDSTLVRIVVTRSE 445

  Fly   468 IDMTDIKVAFERLYGKSLKSWIKGDTSGHYKHALYALVGE 507
            ||:..||..|.::|.|:|.:.|..||||.|:..|.|:||:
  Rat   446 IDLVQIKQMFTQMYQKTLSTMIASDTSGDYRKLLLAIVGQ 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB11	NP_001259616.1	Annexin	209..273	CDD:278615	39/63 (62%)
		Annexin	280..345	CDD:278615	31/64 (48%)
		Annexin	364..429	CDD:278615	30/64 (47%)
		Annexin	439..504	CDD:278615	30/64 (47%)
Anxa7	XP_006251686.2	Annexin	186..251	CDD:395139	39/64 (61%)
		Annexin	258..323	CDD:395139	31/64 (48%)
		Annexin	342..407	CDD:395139	30/64 (47%)
		Annexin	417..482	CDD:395139	30/64 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335647
Domainoid	1	1.000	89	1.000	Domainoid score	I7675
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36149
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2297
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	1	1.000	-	-		mtm9098
orthoMCL	1	0.900	-	-		OOG6_100522
Panther	1	1.100	-	-	LDO	PTHR10502
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810