DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB11 and Anxa5

DIOPT Version :9

Sequence 1:	NP_001259616.1	Gene:	AnxB11 / 32612	FlyBaseID:	FBgn0030749	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_033803.1	Gene:	Anxa5 / 11747	MGIID:	106008	Length:	319	Species:	Mus musculus

Alignment Length:	313	Identity:	139/313 - (44%)
Similarity:	202/313 - (64%)	Gaps:	2/313 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 GTPTVVPAANFDAVKDAHDLRKAMKGFGTDEDALINIICRRSNEQRQEIQRQFKTHFGKDLIEDI 258
            ||.|..|  .||...||..|||||||.|||||:::|::..|||.|||||.::|||.||:||::|:
Mouse     5 GTVTDFP--GFDGRADAEVLRKAMKGLGTDEDSILNLLTSRSNAQRQEIAQEFKTLFGRDLVDDL 67

  Fly   259 KSETSGNFEKLLVGLLRPIVDYYCAELNDAMAGLGTDEEVLIEILCTLSNMEINTIKNQYLRLYG 323
            |||.:|.||||:|.:::|...|...||..|:.|.||||:||.||:.:.:..|::.||..|...||
Mouse    68 KSELTGKFEKLIVAMMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELSAIKQVYEEEYG 132

  Fly   324 AHLESELKSETSGNFKRLLTSLCTAARDESGRVDPVAAKNDARELLKAGELRVGTDESMFNMILC 388
            ::||.::..:|||.::|:|..|..|.||....:|....:.||:.|.:||||:.||||..|..|..
Mouse   133 SNLEDDVVGDTSGYYQRMLVVLLQANRDPDTAIDDAQVELDAQALFQAGELKWGTDEEKFITIFG 197

  Fly   389 QRNYQQLKLIFQEYEGMTGHSLEKAIKKEFSGDVMEGLIAIYRCVTNKAEYFASRLHKAMAGIGT 453
            .|:...|:.:|.:|..::|..:|:.|.:|.||::.:.|:|:.:.:.:...|.|..|:.||.|.||
Mouse   198 TRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGT 262

  Fly   454 NDTQLIRVIITRSEIDMTDIKVAFERLYGKSLKSWIKGDTSGHYKHALYALVG 506
            :|..||||:::|||||:.:|:..|.:.:..||.|.|||||||.||.||..|.|
Mouse   263 DDHTLIRVVVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCG 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB11	NP_001259616.1	Annexin	209..273	CDD:278615	40/63 (63%)
		Annexin	280..345	CDD:278615	26/64 (41%)
		Annexin	364..429	CDD:278615	24/64 (38%)
		Annexin	439..504	CDD:278615	34/64 (53%)
Anxa5	NP_033803.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	13..84		42/70 (60%)
		Annexin	18..82	CDD:278615	40/63 (63%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	85..156		28/70 (40%)
		Annexin	89..154	CDD:278615	26/64 (41%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	168..240		25/71 (35%)
		Annexin	173..238	CDD:278615	24/64 (38%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	244..315		35/70 (50%)
		Annexin	248..313	CDD:278615	34/64 (53%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000250\|UniProtKB:P08758	312..318		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831965
Domainoid	1	1.000	89	1.000	Domainoid score	I7815
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	1	1.000	-	-		mtm8852
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750