DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB11 and Anxa4

DIOPT Version :9

Sequence 1:	NP_001259616.1	Gene:	AnxB11 / 32612	FlyBaseID:	FBgn0030749	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001318049.1	Gene:	Anxa4 / 11746	MGIID:	88030	Length:	319	Species:	Mus musculus

Alignment Length:	310	Identity:	158/310 - (50%)
Similarity:	210/310 - (67%)	Gaps:	0/310 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 TVVPAANFDAVKDAHDLRKAMKGFGTDEDALINIICRRSNEQRQEIQRQFKTHFGKDLIEDIKSE 261
            ||..|:.|:|.:||..|||||||.||||||:|.|:..|:..|||||:..:|:..|:|||||:|||
Mouse     7 TVKAASGFNATEDAQTLRKAMKGLGTDEDAIIGILAYRNTAQRQEIRSAYKSTIGRDLIEDLKSE 71

  Fly   262 TSGNFEKLLVGLLRPIVDYYCAELNDAMAGLGTDEEVLIEILCTLSNMEINTIKNQYLRLYGAHL 326
            .|.|||::::||:.|.|.|...||..||.|.||||..|||||.:.:..||..|...|.:.||..|
Mouse    72 LSSNFEQVILGLMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRINQTYQQQYGRSL 136

  Fly   327 ESELKSETSGNFKRLLTSLCTAARDESGRVDPVAAKNDARELLKAGELRVGTDESMFNMILCQRN 391
            |.::.|:||..|:|:|.||..|.|||...:|....|.||:||.:|||.|.||||..|..|||.||
Mouse   137 EEDICSDTSFMFQRVLVSLSAAGRDEGNYLDDALMKQDAQELYEAGEKRWGTDEVKFLSILCSRN 201

  Fly   392 YQQLKLIFQEYEGMTGHSLEKAIKKEFSGDVMEGLIAIYRCVTNKAEYFASRLHKAMAGIGTNDT 456
            ...|..:|.||:.::...:|::||.|.||...:.|:||.:|:.:|..|||.||:|:|.|:||:|.
Mouse   202 RNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRSKPSYFAERLYKSMKGLGTDDN 266

  Fly   457 QLIRVIITRSEIDMTDIKVAFERLYGKSLKSWIKGDTSGHYKHALYALVG 506
            .||||:::|:||||.||:.:|:|||||||.|:|||||||.|:..|..|.|
Mouse   267 TLIRVMVSRAEIDMLDIRASFKRLYGKSLYSFIKGDTSGDYRKVLLVLCG 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB11	NP_001259616.1	Annexin	209..273	CDD:278615	37/63 (59%)
		Annexin	280..345	CDD:278615	29/64 (45%)
		Annexin	364..429	CDD:278615	29/64 (45%)
		Annexin	439..504	CDD:278615	40/64 (63%)
Anxa4	NP_001318049.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	14..85		41/70 (59%)
		Annexin	19..83	CDD:395139	37/63 (59%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	86..157		33/70 (47%)
		Annexin	90..155	CDD:395139	29/64 (45%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	169..241		32/71 (45%)
		Annexin	173..239	CDD:395139	29/65 (45%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	245..316		42/70 (60%)
		Annexin	249..314	CDD:395139	40/64 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831983
Domainoid	1	1.000	89	1.000	Domainoid score	I7813
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	1	1.000	-	-		mtm8852
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4028
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.890