Protein Alignment tau and map2

DIOPT Version :9

• Sequence 1: NP_733224.2
• Gene: tau / 326116
• FlyBaseID: FBgn0266579
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_031748635.1
• Gene: map2 / 780043
• XenbaseID: XB-GENE-5945202
• Length: 1865
• Species: Xenopus tropicalis
• Alignment Length: 769
• Identity: 185/769 - (24%)
• Similarity: 286/769 - (37%)
• Gaps: 212/769 - (27%)

  Fly    16 PQDYPVQQQRAQSKSEYVMNSASVDRPQQQSRPQPTQDYVPFESSDSSVERK--KEQPSAQLSTD 78
            |:::..|:|..:   ||.......|. .::...:.|.|     :.:..:|.|  .|:|:...:.|
 Frog  1238 PKEHETQKQLDE---EYDEEKEETDE-TEEGDIETTSD-----APEQEIEAKIPDEEPAVGFTDD 1293

  Fly    79 YTN---------------SNTTSDSASYGSDSV---SKQQIRSQQNPEYQNNAYEAPRDDR---- 121
            ...               ..|..|.:...:.||   :...:.|::..|...:..|...:.|
 Frog  1294 VAGVIESVVTVDEDFIQVVQTAVDDSEIMAHSVHFATSAPVESEEKLELDEDIEEVKDEPREGSP 1358

  Fly   122 -SQLQPQRSQPA-TDYSAYERQQRPPPTTLDYTT------GYNAPPKDRTTLSRTNSRPTLSSPN 178
             :...||:.... |||....:......||:|.:.      ..:....||:.::..
 Frog  1359 CAPASPQKEDTQFTDYKTETQDDYRDETTIDDSVLDTDSIWVDTQDDDRSIMTEA---------- 1413

  Fly   179 PKLQSIPNTEYV-RPPQNFVLPPQMRPAVGPPQPRPPFAGARPMVGMGPRPPMPPNMAARPPPLR 242
              :::||..:.. |..|        |..:...:...|....|..:....|     .||.|.|...
 Frog  1414 --IEAIPKEDKAERELQ--------RTYIDKHRKEKPLKSGRARISTPER-----KMAKREPSAT 1463

  Fly   243 STDSKSNLLMGPPMRPGMPPQLNMQQARLPNAGGQLSPPGQGPPRPPGGFPWNPAGAPGMPPGAR 307
            ..|                 ::..::|.|..|........|         |.:|:....:.|..|
 Frog  1464 CRD-----------------EVRRKKAVLKKAETTKKADVQ---------PHSPSRKIILKPAVR 1502

  Fly   308 PPQNMTRPPPPTFARPPPGQPLQAPFNRPPFNQPPMQPQQQQPPQQLQQQQQQQQQQQHMQQQQQ 372
                .:||...:..|                 :.|...:.||.|
 Frog  1503 ----QSRPTHQSCVR-----------------RKPAGGESQQTP--------------------- 1525

  Fly   373 LRPLSAASAHNNNDDDDDVVMGPAVTPLKTFNSRPDPMGEPLLEDIEPPFQTSPPAGESKKGPGF 437
                   |||  ....|.|:.|.:.:|.|. :|.|.|      ..|.|          .:|....
 Frog  1526 -------SAH--RQPRDRVMDGVSRSPEKR-SSLPRP------SSIHP----------IRKVYAD 1564

  Fly   438 KGDN--------DSGVDESTQEK---DRNGPNSPSSPVKTPTSTSSKPDKSGTSRPPS------- 484
            |.||        .|.|..:|:.:   .|.|.:..|:|. ||.||:..|   ||  |||
 Frog  1565 KEDNSLSTSTSVSSSVRRTTRSEPIWSRTGKSGTSTPT-TPGSTAITP---GT--PPSYASRTPG 1623

  Fly   485 --ATPSNKSAPKSRSASKNRLL--------LKTPEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIG 539
              .|||....|::....|:.:|        |:||...|...   .::::.|.|.|:||.:|||||
 Frog  1624 TPGTPSYSRTPRTPGTPKSAMLYSEKKVAMLRTPPKSPATP---KQIRIFHQPLPDLKNIRSKIG 1685

  Fly   540 SLDNATYKPGGGHVKIESKKIDIK-AAPRIEAK-NDKYMPKGGEKKIVTTKLQW-NAKSKIGSLE 601
            |.||..|:|.||.|||.::|||.. ...|..:| |..:...||:.:||:.|:.. :..||.|||:
 Frog  1686 STDNMKYQPKGGQVKILNEKIDYSDVQSRCGSKDNISHNAGGGQVQIVSKKINLSHVTSKCGSLK 1750

  Fly   602 NAAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGDIKIQTQKLEIKAQSKVGSLDN-- 664
            |..||||||..:||::|:|||:||..|:||..|..|.||||:|||.:|||..:.|:| ..:|:
 Frog  1751 NIRHKPGGGHVRIESVKLDFKEKAHAKIGSLDNAHHTPGGGNIKIDSQKLHFREQAK-ARVDHGA 1814

  Fly   665 --VKHKPGGGEKKIFDDKDYLKNVEHSVA---LTTPPTQSPLPSMTASGADENL 713
              |...||   :........|.||..|.:   |.:|...:....:||:.|.:.|
 Frog  1815 EIVSQSPG---RSSAASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 1865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	Tubulin-binding	521..551	CDD:278828	15/29 (52%)
		Tubulin-binding	583..610	CDD:278828	13/27 (48%)
		Tubulin-binding	613..642	CDD:278828	15/28 (54%)
		Tubulin-binding	644..672	CDD:278828	12/31 (39%)
map2	XP_031748635.1	MAP2_projctn	434..1515	CDD:369841	55/357 (15%)
		Tubulin-binding	1667..1698	CDD:395337	16/30 (53%)
		Tubulin-binding	1699..1729	CDD:395337	10/29 (34%)
		Tubulin-binding	1730..1759	CDD:395337	13/28 (46%)
		Tubulin-binding	1761..1792	CDD:395337	16/30 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12214
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48352
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8371
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030