Protein Alignment tau and mapt

DIOPT Version :9

• Sequence 1: NP_733224.2
• Gene: tau / 326116
• FlyBaseID: FBgn0266579
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_012808014.2
• Gene: mapt / 779920
• XenbaseID: XB-GENE-986948
• Length: 709
• Species: Xenopus tropicalis
• Alignment Length: 825
• Identity: 175/825 - (21%)
• Similarity: 273/825 - (33%)
• Gaps: 322/825 - (39%)

  Fly     6 KDRSGQEII------SPQDYPVQQQ--------RAQSKSEYVMNSASVDRPQQQSRPQPTQDYVP 56
            :||:.:||.      ..::|.:...        :.|:.:|....:..||...|......:...|
 Frog    91 QDRAAEEIALLAAAGQEEEYEMDTMEETLKITAKDQTHAENYGITGDVDGESQNDETALSSGMV- 154

  Fly    57 FESSDSSVERK--KEQPSAQLSTDYTNSNTTS-----DSASYGSDSVS-----KQQIRSQQNPEY 109
                :|:||..  ||....:::.:....:|..     |......|||:     :|::.|.:.|:.
 Frog   155 ----ESAVEEDYYKETNGKEVNLEICEDDTEGWEEQIDEGIIMQDSVAPPKGGEQELSSVEQPQT 215

  Fly   110 QNNA-----YEAPRDDRSQLQPQRSQPATDYSAYERQQRPPPTTLDYTTGYNAP----------- 158
            ....     .|..:..:...:|..:.||..:...:.:.|...:........|.|
 Frog   216 NGTGAEHIFLEDNQHKKDTEEPFMAIPANSFPVGQIRPRASVSVYQVEIDANIPIDSKEAPCEDV 280

  Fly   159 --PKDRTTLSRTNSRPTLSSPNPKL----QSIP--------------------------NTEYVR 191
              |......:...:..||.||..::    ..||                          :|::
 Frog   281 GIPGGTKVDTERATEETLKSPRKRMPAHGSGIPVSRVPVPKAHEQEKHETDSQEKGAQISTKH-- 343

  Fly   192 PP-----QNFVLPPQMRPAVGPPQPRPPFAGARPMVGMGPRPPMPPNMAARPPPLRSTDSKSNLL 251
            ||     ......||..|::....|..|.|.:                      :||....|
 Frog   344 PPAKNAKSRLYTVPQKSPSITSKSPSSPAASS----------------------VRSIQRTS--- 383

  Fly   252 MGPPMRPGMPPQLNMQQARLPNAGGQLSPPGQGPPRPPGGFPWNPAGAPGMPPGARPPQNMTRPP 316
            :|...:||:..:|:    |...|||                   |..|......:|...:.:|.|
 Frog   384 LGAVGQPGVTARLH----RAKEAGG-------------------PESAKSQLSASRNATSASRIP 425

  Fly   317 PPTFARPPPGQPLQAPFNRPPFNQPPMQPQQQQPPQQLQQQQQQQQQQQHMQQQQQLRPLSAASA 381
            ..|.:.|                        :.||..:::.|:
 Frog   426 AKTSSIP------------------------KTPPSAVRRDQR---------------------- 444

  Fly   382 HNNNDDDDDVVMGPAVTPLKTFNSRPDPMGEPLLEDIEPPFQTSPPAGESKKGPGFKGDNDSGVD 446
                                    :|.|.|      .:|....||.:||
 Frog   445 ------------------------KPPPSG------AKPDRAESPKSGE---------------- 463

  Fly   447 ESTQEKDRNGPNSPSSPVKTPTSTSSKPDKSGTSRPPSATPSN----KSAPKSRSASKNRLLLKT 507
                   |:|.:||.|| .|||..||      :..||:..|..    ::.|||.:::|:||
 Frog   464 -------RSGYSSPGSP-GTPTGRSS------SQTPPTREPKKIAVIRTPPKSPASAKSRL---- 510

  Fly   508 PEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIGSLDNATYKPGGGHVKIESKKIDIKAAPRIEAKN 572
               :||         ...|..|:||.|||||||:||..::||||.|:|..||||:.
 Frog   511 ---QPV---------TSPAAMPDLKNVRSKIGSIDNIRHQPGGGKVQIVHKKIDLS--------- 554

  Fly   573 DKYMPKGGEKKIVTTKLQWNAKSKIGSLENAAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKH 637
                               :.:||.||.:|..|.||||..:|....:|. .....|.||..|:.|
 Frog   555 -------------------SVQSKCGSKDNLKHMPGGGTIQITHKPIDL-THITSKCGSFGNIHH 599

  Fly   638 QPGGGDIKIQTQKLEI-KAQSKVGSLDNVKHKPGGGEKKIFDDK-----------DY-------- 682
            :||||:::::::|||. |.|||:|||||:.|.||||.|||...|           |:
 Frog   600 RPGGGNVEVKSEKLEFDKIQSKIGSLDNITHTPGGGAKKIESHKLMFRENAKAKTDHGAEIVYKS 664

  Fly   683 -----------LKNVEHSVALTTPPTQSPLPSMTASGADENLNQQ 716
                       |.||..|.::..  |.||..|..|.....:|.:|
 Frog   665 PGQSGETSPRRLSNVSSSGSINM--TDSPQLSTLADQVSASLAKQ 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	Tubulin-binding	521..551	CDD:278828	15/29 (52%)
		Tubulin-binding	583..610	CDD:278828	8/26 (31%)
		Tubulin-binding	613..642	CDD:278828	9/28 (32%)
		Tubulin-binding	644..672	CDD:278828	15/28 (54%)
mapt	XP_012808014.2	PHA03378	<199..520	CDD:223065	78/492 (16%)
		PTZ00449	<383..>512	CDD:185628	47/267 (18%)
		Tubulin-binding	<521..543	CDD:395337	14/21 (67%)
		Tubulin-binding	544..573	CDD:395337	14/56 (25%)
		Tubulin-binding	575..605	CDD:395337	10/30 (33%)
		Tubulin-binding	606..635	CDD:395337	15/28 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005553
OrthoInspector	1	1.000	-	-		otm48352
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8371
SonicParanoid	1	1.000	-	-		X4510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030