Protein Alignment tau and map2

DIOPT Version :10

• Sequence 1: NP_733224.2
• Gene: tau / 326116
• FlyBaseID: FBgn0266579
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_009303136.1
• Gene: map2 / 450004
• ZFINID: ZDB-GENE-041010-118
• Length: 1741
• Species: Danio rerio
• Alignment Length: 700
• Identity: 158/700 - (22%)
• Similarity: 268/700 - (38%)
• Gaps: 155/700 - (22%)

  Fly    11 QEIISPQDYPVQQQRAQSKSEYVMNSASVDRPQQQSRPQPTQDYVPFESSDSSVERKKEQPSAQL 75
            :.:::.:|..:...:...|||...:|.....|.::..||..|:           |.::|:.|.::
Zfish  1087 ESVVTVEDDFITVVQTIDKSEVSGHSVRFSAPSEEEHPQLLQE-----------EEEEEEESVEM 1140

  Fly    76 STDYTNSNTTSDSASYGSDSVSKQQIRSQQNPEYQNNAYEAPRDDRSQLQ-PQRSQPATDYSAYE 139
            :.:..            .::.|.::|.....|      .|.|.....:|: |:...|...|..|:
Zfish  1141 AQEVE------------MEAPSLEEIVDVPEP------VEPPVCPAKELEVPESEAPTQSYDDYK 1187

  Fly   140 RQQRPPPTTLDYTTGYNAPPKDRTTLSRTNSRPTLSSPNPKLQSIPNTEYVRPPQNFVLPPQMRP 204
            .:.....:.|| ::..:....||            |....|::.:|.          |..|..:|
Zfish  1188 DETTIDDSILD-SSWVDTQDDDR------------SMATEKIEPLPR----------VKSPVKKP 1229

  Fly   205 AVGPP-QPRPPFAGARPMVGMGPRPPMPPNMAARPPPLRSTD--------------SKSNLLMGP 254
            |...| :|:.....|:..:....|.|    :...|.||:..:              .||::....
Zfish  1230 AAEKPVKPKAKGGRAKGRISTPERKP----VRKEPLPLQKDEMKKKKAVIKKAEFTKKSDIQTCS 1290

  Fly   255 PMRPGM---------PPQLNMQQARLPNAGGQLSPPGQGPPRPPGGFPWNPAGAPGMPPGARPPQ 310
            |.|..:         |.|.:....|.|.....            |..|::.|...........|.
Zfish  1291 PSRKSVLKATVRHPRPTQHHACVKRKPTVSAD------------GRLPFSVARHSRDRASTSNPT 1343

  Fly   311 NMTRPPPPTF-------ARPPPGQPLQAPFNRPPFNQPPMQPQQQQPPQQLQQQQQQQQQQQHMQ 368
            .:|:.|....       |||...............:...::|....|...:.....:..:.:..:
Zfish  1344 TLTKIPTSKIRAEALLPARPNSASSSNKRSQLVETDLYELRPASAGPQVSINIYHVKDGRSRSPE 1408

  Fly   369 QQQQL-RPLSAASAHN----NNDDDDDVVMGPAVTPLKTFNSRPDPMGEPLLEDIEPPFQTSPPA 428
            ::..| ||.|..:..:    :.:....:....:..|.:..:.|.:             .:|....
Zfish  1409 KRSSLPRPASILTRRSHMAEHEESSTSITSSGSTAPRRPTSFRTE-------------VRTDHRT 1460

  Fly   429 GESKKGPGFKGDNDSGVDESTQEKDRNGPNSPSSPVKTPTSTSSKPDKSGTSRPPS------ATP 487
            |.|....|    .:||...|.    |:|.::|    .||.||:..|   ||  |||      .||
Zfish  1461 GRSHSATG----TESGRSRSA----RSGTSTP----HTPGSTAITP---GT--PPSYSCRTPGTP 1508

  Fly   488 SNKSAPKS---RSASKNRLLLKTPEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIGSLDNATYKPG 549
            .....|||   .|..|...:::||...|.  ....:::|.:.|.|:||.:||||||:||..|:|.
Zfish  1509 RTPGTPKSLSLLSQEKKVAIIRTPPKSPA--TTPKQLRVLNQPLPDLKNIRSKIGSIDNIKYQPK 1571

  Fly   550 GGHVKIESKKIDIKAAPRIEAK-----NDKYMPKGGEKKIVTTKLQW-NAKSKIGSLENAAHKPG 608
            ||.:.|.:||:|..   .:::|     |.|:.|:||...|.:.|:.. :..||.|||:|..|:||
Zfish  1572 GGQILILNKKLDFS---HVQSKCGSKDNLKHSPRGGNIHIQSKKIDLSHVTSKCGSLDNIRHRPG 1633

  Fly   609 GGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGDIKIQTQKLEIKAQSK 658
            ||..:||::|:||::||..||||..|..|.||||.|:|::.||..:..:|
Zfish  1634 GGHVRIESVKLDFREKAHAKVGSLDNAHHTPGGGQIQIESHKLSFRDAAK 1683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	PHA03247	<113..529	CDD:223021	83/461 (18%)
		Tubulin-binding	521..551	CDD:459807	15/29 (52%)
		Tubulin-binding	582..610	CDD:459807	11/28 (39%)
		Tubulin-binding	612..642	CDD:459807	15/29 (52%)
		Tubulin-binding	644..672	CDD:459807	4/14 (29%)
map2	XP_009303136.1	MAP2_projctn	418..1316	CDD:429957	47/284 (17%)
		Tubulin-binding	1544..1573	CDD:459807	15/28 (54%)
		Tubulin-binding	1575..1604	CDD:459807	8/31 (26%)
		Tubulin-binding	1608..1635	CDD:459807	11/26 (42%)
		Tubulin-binding	1637..1667	CDD:459807	15/29 (52%)