Protein Alignment tau and MAP4

DIOPT Version :10

• Sequence 1: NP_733224.2
• Gene: tau / 326116
• FlyBaseID: FBgn0266579
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_024309291.1
• Gene: MAP4 / 4134
• HGNCID: 6862
• Length: 2326
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 186/735 - (25%)
• Similarity: 280/735 - (38%)
• Gaps: 161/735 - (21%)

  Fly    20 PVQQQRAQSKSEYVMNSASVDRPQQQSRPQPTQDYVPFESSDSSVERK----KEQPSAQLSTDYT 80
            ||:.|....::..:...|  ||....:.|...:.    |:.:.||..:    .|..:.:||  :.
Human  1609 PVEDQSLPGEARALEGYA--DRGNFPAHPVNEEK----ETKEGSVAVQIPDLLEDKAQKLS--FC 1665

  Fly    81 NSNTTSDSASYGSDSVSKQQIRSQQNPEYQNN-------AYEAPRDDRSQLQPQRSQPATDYSAY 138
            ......|..|.||||::|:...:..:|:.:|:       |.:....:...|.....|  :|: .:
Human  1666 EDQNAQDRNSKGSDSLNKKVDLTLLSPKSENDKLKEISLACKITELESVSLPTPEIQ--SDF-LH 1727

  Fly   139 ERQQRPPPTTLD------YTTGYNAP-PKDR--TTLSRTNSRPTLSSP------NPKLQSIPNTE 188
            .:.:.||....|      .:.|...| |||:  .|..:...:....:|      :....:.|...
Human  1728 SKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKG 1792

  Fly   189 YVRPPQNFVLPP--------------QMRPAV----------------GPPQPRPPFAGARPMV- 222
            |:||.::..|.|              |::.||                |..:|..    .||:|
Human  1793 YMRPTKSRGLTPLLPKSTIQEQERHKQLKSAVCLSSSTVYQQLGMSVYGIARPEE----GRPVVS 1853

  Fly   223 GMGPRPPMPPNMAARPPPLRSTDSKSNLLMGPPMRPGMPPQLNMQQARLPNAGGQLSPPGQGPPR 287
            |.|.....|||....|.|.:.|         .|:....|.:.:..:|:..    ..|.|.|..|.
Human  1854 GTGNDITTPPNKELPPSPEKKT---------KPLATTQPAKTSTSKAKTQ----PTSLPKQPAPT 1905

  Fly   288 PPGGFPWNPAG-APGMPPGA---RPPQNMTRPP--PPTFARPPPGQPLQAPFNRPPFNQPPMQPQ 346
            ..||....|.. |.|:.|.|   ||.....||.  |....:|.|....:||..|...::|...|.
Human  1906 TIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPA 1970

  Fly   347 QQQPPQQLQQQQQQQQQQQHMQQQQQLRPLSAASAHNNNDDDDDVVMGPAVTPLKTFNSRPDPMG 411
            .:...:               ..|...:..:||:..:..
Human  1971 SRSGSK---------------STQTVAKTTTAAAVASTG-------------------------- 1994

  Fly   412 EPLLEDIEPPFQTSPPAGESKKGPGFKGDNDSGVDESTQEKDRNGPNSPSSPVKTPTSTSSKPDK 476
                     |...||.....||....|.:....  |..:...::.|...|.|..|.||:..|...
Human  1995 ---------PSSRSPSTLLPKKPTAIKTEGKPA--EVKKMTAKSVPADLSRPKSTSTSSMKKTTT 2048

  Fly   477 -SGTSRPPSATPSN-KSAPKSRSASKNRLLLKTP-EPEPVKKVPMNKVQVGHAPSPNLKAVRSKI 538
             |||:......||. |:.|.....|....:.|.| ..:|....|.......:..:|:||.||||:
Human  2049 LSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKV 2113

  Fly   539 GSLDNATYKPGGGHVKIESKKIDIKAAPRIEAKNDKYMPKG----------GEKKIVTTKLQW-N 592
            ||.:|..::||||..|:| ||.:..|..|....|......|          |:.:||:.|:.: :
Human  2114 GSTENIKHQPGGGRAKVE-KKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSH 2177

  Fly   593 AKSKIGSLENAAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGDIKIQTQKLEI--KA 655
            .:||.||.:|..|.||||:.:|:..|:|. .|...|.||.||:||:|||||:||::|||..  ||
Human  2178 IQSKCGSKDNIKHVPGGGNVQIQNKKVDI-SKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKA 2241

  Fly   656 QSKVGSLDNVKHKPGGGEKK 675
            |:||||||||.|.|.||..|
Human  2242 QAKVGSLDNVGHLPAGGAVK 2261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	PHA03247	<113..529	CDD:223021	91/470 (19%)
		Tubulin-binding	521..551	CDD:459807	12/29 (41%)
		Tubulin-binding	582..610	CDD:459807	11/28 (39%)
		Tubulin-binding	612..642	CDD:459807	13/29 (45%)
		Tubulin-binding	644..672	CDD:459807	18/29 (62%)
MAP4	XP_024309291.1	PHA03247	<1844..2093	CDD:223021	66/317 (21%)
		Tubulin-binding	<2105..2126	CDD:459807	11/20 (55%)
		Tubulin-binding	2166..2195	CDD:459807	11/28 (39%)
		Tubulin-binding	2197..2226	CDD:459807	13/29 (45%)
		Tubulin-binding	2228..2258	CDD:459807	18/29 (62%)