DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tau and MAP2

DIOPT Version :9

Sequence 1:	NP_733224.2	Gene:	tau / 326116	FlyBaseID:	FBgn0266579	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001362433.1	Gene:	MAP2 / 4133	HGNCID:	6839	Length:	1915	Species:	Homo sapiens

Alignment Length:	798	Identity:	186/798 - (23%)
Similarity:	297/798 - (37%)	Gaps:	235/798 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ISPQDYPVQQQRAQSKSEYVMNS-ASVDRPQQQSRPQPTQDYVPFES-----SDSSVERKKEQ-- 70
            |:|.|.      |:...|.:::. |.:...:::...|...|.:.|.|     :|..|...:|:
Human  1212 ITPSDV------AEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFV 1270

  Fly    71 ---PS---------AQLSTDY-TNSNTTSDSASYGSDSV---SKQQIRSQQNPE-YQNNAYEAPR 118
               ||         ..:..|: |...||:|....||.||   :.:|...::.|. :....:|...
Human  1271 ETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEE 1335

  Fly   119 DDRSQLQPQRSQPATDYSAYERQQRPPPTTLDYTTGYNAPPKDRTTL-------------SRTNS 170
            ...:|.:|:...|....|    .:|......:|.|......||.||:             ::.:.
Human  1336 AAEAQAEPKDGSPEAPAS----PEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDD 1396

  Fly   171 RPTLSSPNPKLQSIPNTEYVRPPQNFVLPPQMRPAVGPPQPRPPFAGARPMVGMGPRPPMPPNMA 235
            |..::.   :|::||..|.......       |.::...:...||...|..:....|     .:|
Human  1397 RSIMTE---QLETIPKEEKAEKEAR-------RSSLEKHRKEKPFKTGRGRISTPER-----KVA 1446

  Fly   236 ARPPPLRSTD---------SKSNL---------------LMGPPMRPGMPPQLNMQQARLPNAGG 276
            .:.|...|.|         .|:.|               ::.|.::...|..|:..:.:...|||
Human  1447 KKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGG 1511

  Fly   277 QLSPPGQGPPRPPGGFPWNPAGAPGMPPGARPP---QNMTRPP-------PPTFARPPPGQPLQA 331
            :                  .|.||.:...|:..   ..:::.|       .|.::...|....:|
Human  1512 E------------------SALAPSVFKQAKDKVSNSTLSKIPALQGSTKSPRYSSACPSTTKRA 1558

  Fly   332 PFNRPPFNQPPMQPQQQQPPQQLQQQQQQQQQQQHMQQQQQLRPLSAASA----HNNNDDDDDVV 392
            .|:                                  ....::|.||.|.    ::.:.:.|.|.
Human  1559 TFS----------------------------------DSLLIQPTSAGSTDRLPYSKSGNKDGVT 1589

  Fly   393 MGPAVTPLKTFNSRPDPMGEPLLEDIEPPFQTSPPAGESKKGPGFKGDND-------SGVDESTQ 450
            ..|     :..:|.|.|      ..|.||.:            |..||.|       |.:..|.:
Human  1590 KSP-----EKRSSLPRP------SSILPPRR------------GVSGDRDENSFSLNSSISSSAR 1631

  Fly   451 EKDR---------NGPNSPSSPVKTPTSTSSKPDKS----GTSRPPS--ATPSNKSAPKSR---S 497
            ...|         :|.::|::|..|..:..:.|..|    ||...||  .||.....|||.   .
Human  1632 RTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVP 1696

  Fly   498 ASKNRLLLKTPEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIGSLDNATYKPGGGHVKIESKKIDI 562
            :.|...:::||...|...   .::::.:.|.|:||.|:|||||.||..|:|.||.|:|.:||||.
Human  1697 SEKKVAIIRTPPKSPATP---KQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVRILNKKIDF 1758

  Fly   563 -KAAPRIEAK-NDKYMPKGGEKKIVTTKLQW-NAKSKIGSLENAAHKPGGGDKKIETLKMDFKDK 624
             |...|..:| |.|:...||..:|||.|:.. :..||.|||:|..|:||||..|||::|:|||:|
Human  1759 SKVQSRCGSKDNIKHSAGGGNVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEK 1823

  Fly   625 AKPKVGSTANVKHQPGGGDIKIQTQKLEIKAQSKVGSLDNVKHKPGGGEKKIFDDKDYLKNVEHS 689
            |:.||||..|..|.||||::||.:|||..:..:|.                         .|:|.
Human  1824 AQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKA-------------------------RVDHG 1863

  Fly   690 VALTTPPTQSPLPSMTAS 707
            ..:.   ||||..|..||
Human  1864 AEII---TQSPGRSSVAS 1878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	Tubulin-binding	521..551	CDD:278828	14/29 (48%)
		Tubulin-binding	583..610	CDD:278828	13/27 (48%)
		Tubulin-binding	613..642	CDD:278828	17/28 (61%)
		Tubulin-binding	644..672	CDD:278828	6/27 (22%)
MAP2	NP_001362433.1	MAP2_projctn	377..1505	CDD:369841	57/317 (18%)
		PTZ00449	<1531..1745	CDD:185628	57/273 (21%)
		Tubulin-binding	1717..1747	CDD:366087	14/29 (48%)
		Tubulin-binding	1749..1778	CDD:366087	11/28 (39%)
		Tubulin-binding	1780..1809	CDD:366087	13/28 (46%)
		Tubulin-binding	1811..1841	CDD:366087	17/29 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12210
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41144
orthoMCL	1	0.900	-	-		OOG6_106583
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8371
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930