Protein Alignment tau and Map4

DIOPT Version :9

• Sequence 1: NP_733224.2
• Gene: tau / 326116
• FlyBaseID: FBgn0266579
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_006243875.1
• Gene: Map4 / 367171
• RGDID: 1564359
• Length: 2203
• Species: Rattus norvegicus
• Alignment Length: 750
• Identity: 174/750 - (23%)
• Similarity: 282/750 - (37%)
• Gaps: 231/750 - (30%)

  Fly    18 DYPVQQQRAQSKSEYVMNSASVDRPQQ-----------QSRPQPTQDYVPFESSDSSVE------ 65
            |.||...:.:.::|  .:||.|..|..           .::.:..:|....||.|..|:
  Rat  1529 DLPVSLMKEEKRTE--KDSAPVRNPDPLRQKAQKFSLCDNQNKKERDSKGPESLDKKVDITLLPP 1591

  Fly    66 --RKKEQPSAQLSTDYTNSN-----TTSDSASYGSDSVSKQQ------IRSQQNPEYQNNAYEAP 117
              .|.:.....||.:.|...     ||:..:.:..|||..:.      .:..|.||::.|..|||
  Rat  1592 ENEKAKLKETNLSCEVTKLECISMLTTALQSDFSCDSVEGESNVVVTAYKDPQVPEFKGNEVEAP 1656

  Fly   118 ----------------RDDRSQ------LQPQRSQPATDYSAYERQQRPPPTTLDYTTGYNAPPK 160
                            ::|:|:      ::|.:|:..|.:......|......|...:|.:...:
  Rat  1657 QKITGKSELKVLDERKKEDKSKMAVKGYMRPTKSRGPTPHQPKSASQERERAKLLKASGVSRQEE 1721

  Fly   161 DRTTLSRTNSRPTLSSPNPKLQSIPNTE-----YVRPPQNFVLPPQMRPAVGPPQPRPPFAGA-- 218
            .:..:..|.: ...:.||.:|...|..:     ..:|.:......:::|...|.||.|..:|.
  Rat  1722 GKAAVGLTGN-DIATPPNKELPPSPEKKAKPLATTQPAKTSTSKAKIQPTSLPKQPAPTTSGGLN 1785

  Fly   219 -RPM-VGMGPRPPMP---PNMA---ARPPPLRSTDSKSNLLMGPPMRPGMPPQLNMQQARLPNAG 275
             :|| :..|..|..|   |..|   |||..|.:.|          ::|....:..:.:.|..
  Rat  1786 KKPMSLASGSVPAAPHKRPAAATATARPSTLPARD----------LKPKPITETKVAEKRTS--- 1837

  Fly   276 GQLSPPGQGPPRPPGGFPWNPAGAPGMPPGARPPQNMTRPPPPTFARPPPGQPLQAPFNRPPFNQ 340
                             |..|:.||.:.||.:....:::...|: .....|...::|....|  :
  Rat  1838 -----------------PSKPSSAPALRPGPKTTPTISKATSPS-TLVSTGSSSRSPSTTLP--K 1882

  Fly   341 PPMQPQQQQPPQQLQQQQQQQQQQQHMQQQQQLRPLSAASAHNNNDDDDDVVMGPAVTPLKTFNS 405
            .|...:.:..|..:::...:..    .....:.:..||:|...|.
  Rat  1883 RPTTTKTEGKPADVKRMTAKSA----TADLSRSKTTSASSVKRNT-------------------- 1923

  Fly   406 RPDPMGEPLLEDIEPPFQTSPPAGESKKGPGFKGDNDSGVDESTQEKDRNGPNSPSSPVKTP--T 468
                          .|...:||||.:                ||:.|          |:..|  :
  Rat  1924 --------------TPTGATPPAGMA----------------STRVK----------PMSAPCRS 1948

  Fly   469 STSSKPDKSGTSRPPSATPSNKSAPK-SRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAPSPNLK 532
            |.:...||..||..||:     |||: ||.|:.                         ..:|:||
  Rat  1949 SVALSVDKKPTSTKPSS-----SAPRVSRLATT-------------------------VSAPDLK 1983

  Fly   533 AVRSKIGSLDNATYKPGGGHVKIESK------------------KIDIKAAPRIEAKNDKYMPKG 579
            :||||:||.:|..::||||..|:|.|                  ...|.:||:         |..
  Rat  1984 SVRSKVGSTENMKHQPGGGRAKVEKKTEAATTAGNPEPNAVTKAASSISSAPK---------PPA 2039

  Fly   580 GEKKIVTTKLQW-NAKSKIGSLENAAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGD 643
            |:.:||:.|:.: :.:||.||.:|..|.||||:.:|:..|:|. .|...|.||.||:||:|||||
  Rat  2040 GKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDI-SKVSSKCGSKANIKHKPGGGD 2103

  Fly   644 IKIQTQKLEI--KAQSKVGSLDNVKHKPGGGEKKI 676
            :||::|||..  |||:||||||||.|.|.||..|:
  Rat  2104 VKIESQKLNFKEKAQAKVGSLDNVGHLPAGGTVKV 2138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	Tubulin-binding	521..551	CDD:278828	12/29 (41%)
		Tubulin-binding	583..610	CDD:278828	11/27 (41%)
		Tubulin-binding	613..642	CDD:278828	13/28 (46%)
		Tubulin-binding	644..672	CDD:278828	18/29 (62%)
Map4	XP_006243875.1	Tubulin-binding	<1981..2002	CDD:278828	11/20 (55%)
		Tubulin-binding	2042..2071	CDD:278828	11/28 (39%)
		Tubulin-binding	2073..2102	CDD:278828	13/29 (45%)
		Tubulin-binding	2104..2134	CDD:278828	18/29 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I11867
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45284
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.000