Protein Alignment tau and Map2

DIOPT Version :10

• Sequence 1: NP_733224.2
• Gene: tau / 326116
• FlyBaseID: FBgn0266579
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_017451780.1
• Gene: Map2 / 25595
• RGDID: 3044
• Length: 1942
• Species: Rattus norvegicus
• Alignment Length: 859
• Identity: 194/859 - (22%)
• Similarity: 297/859 - (34%)
• Gaps: 310/859 - (36%)

  Fly     6 KDRSGQEIISPQDYPVQQQRAQSKSEY---VMNSASVDRPQQQSRPQPT--QDYV---------- 55
            |::..:..:..|:...:::..:|..|:   .|.|...|..::::.|:.:  ||.|
  Rat  1200 KEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKPDEGKKETSPETSLIQDEVALKLSVEIPC 1264

  Fly    56 --PFESSDSSVERKKE-----------------------------QPSAQLS------------- 76
              |...:|||::.|.|                             ||.|.:|
  Rat  1265 PPPVSEADSSIDEKAEVQMEFIQLPKEESTETPDIPAIPSDVTQPQPEAVVSEPAEVRGEEEEIE 1329

  Fly    77 -----------------TD--------------------------------YTNSNTTSDSASYG 92
                             ||                                .|...||:|....|
  Rat  1330 AEGEYDKLLFRSDTLQITDLLVPGSREEFVETCPGEHKGVVESVVTIEDDFITVVQTTTDEGELG 1394

  Fly    93 SDSVSKQQIRSQQNPEYQNNAYEAPRDD--------RSQLQPQRSQPATDYSAYERQQRPPPTTL 149
            |.||   :..:...||.:...|  |.|:        .:|.:|:...|  |..|...::..|.:
  Rat  1395 SHSV---RFAAPVQPEEERRPY--PHDEELEVLMAAEAQAEPKDGSP--DAPATPEKEEVPFS-- 1450

  Fly   150 DYTTGYNAPPKDRTTL-------------SRTNSRPTLSSPNPKLQSIPNTEYVRPPQNFVLPPQ 201
            :|.|......||.||:             ::.:.|..|:.   :|::||..|.......
  Rat  1451 EYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSILTE---QLETIPKEERAEKEAR------ 1506

  Fly   202 MRPAVGPPQPRPPFAGARPMVGMGPRPPMPPNMAARPPPLRSTDSKSNLLMGPPMRPGMPPQLNM 266
             ||::...:...||...|..:.      .|....|:..|  ||.|:.              ::..
  Rat  1507 -RPSLEKHRKEKPFKTGRGRIS------TPERKVAKKEP--STVSRD--------------EVRR 1548

  Fly   267 QQARLPNAGGQLSPPGQGPPRPPGGFPWNPAGAPGMPPGARPPQNMTRPPPPTFAR----PPPGQ 327
            ::|....|  :|:...:           ..|.:|......:|....|||...:..:    ...|:
  Rat  1549 KKAVYKKA--ELAKKSE-----------VQAHSPSRKLILKPAIKYTRPTHLSCVKRKTTATSGE 1600

  Fly   328 PLQAPFNRPPFNQPPMQPQQQQPPQQLQQQQQQQQQQQHMQQQQQLRPLSAASAHNNNDDDDDVV 392
            ..|||   ..|.|.                                              .|.|.
  Rat  1601 SAQAP---SAFKQA----------------------------------------------KDKVT 1616

  Fly   393 MGPAVTPLKTFNSRPDPMGEPLLEDIEPPFQTSPPAGESKKG-PGFKGDNDSGVDESTQEKDRNG 456
            .|...:|.|. :|.|.|      ..|.||          ::| .|.:.:|...::.|.....|..
  Rat  1617 DGITKSPEKR-SSLPRP------SSILPP----------RRGVSGDREENSFSLNSSISSARRTT 1664

  Fly   457 PNSP-----SSPVKTPTSTSSKPDKSGTSRPPS------ATPSNKSAPKSRSASKNRLL------ 504
            .:.|     .|...|||:..|.....||  |||      .||...|.|::....|:.:|
  Rat  1665 RSEPIRRAGKSGTSTPTTPGSTAITPGT--PPSYSSRTPGTPGTPSYPRTPGTPKSGILVPSEKK 1727

  Fly   505 ---LKTPEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIGSLDNATYKPGGGHVKIESKKIDI-KAA 565
               ::||...|...   .::::.:.|.|:||.|:|||||.||..|:|.||.|:|.:||||. |..
  Rat  1728 VAIIRTPPKSPATP---KQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVRILNKKIDFSKVQ 1789

  Fly   566 PRIEAK-NDKYMPKGGEKKIVTTKLQW-NAKSKIGSLENAAHKPGGGDKKIETLKMDFKDKAKPK 628
            .|..:| |.|:...||..:|||.|:.. :..||.|||:|..|:||||..|||::|:|||:||:.|
  Rat  1790 SRCGSKDNIKHSAGGGNVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAK 1854

  Fly   629 VGSTANVKHQPGGGDIKIQTQKLEIKAQSKVGSLDNVKHKPGGGEKKIFDDKDYLKNVEHSVALT 693
            |||..|..|.||||::||.:|||..:..:|.                         .|:|...:.
  Rat  1855 VGSLDNAHHVPGGGNVKIDSQKLNFREHAKA-------------------------RVDHGAEII 1894

  Fly   694 TPPTQSPLPSMTAS 707
               ||||..|..||
  Rat  1895 ---TQSPSRSSVAS 1905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	PHA03247	<113..529	CDD:223021	84/461 (18%)
		Tubulin-binding	521..551	CDD:459807	14/29 (48%)
		Tubulin-binding	582..610	CDD:459807	13/28 (46%)
		Tubulin-binding	612..642	CDD:459807	17/29 (59%)
		Tubulin-binding	644..672	CDD:459807	6/27 (22%)
Map2	XP_017451780.1	MAP2_projctn	460..1593	CDD:429957	74/446 (17%)
		PTZ00449	<1498..1772	CDD:185628	76/386 (20%)
		Tubulin-binding	1745..1774	CDD:459807	14/28 (50%)
		Tubulin-binding	1776..1805	CDD:459807	11/28 (39%)
		Tubulin-binding	1807..1836	CDD:459807	13/28 (46%)
		Tubulin-binding	1838..1868	CDD:459807	17/29 (59%)