Protein Alignment tau and Mapt

DIOPT Version :10

• Sequence 1: NP_733224.2
• Gene: tau / 326116
• FlyBaseID: FBgn0266579
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_036012271.1
• Gene: Mapt / 17762
• MGIID: 97180
• Length: 767
• Species: Mus musculus
• Alignment Length: 840
• Identity: 207/840 - (24%)
• Similarity: 310/840 - (36%)
• Gaps: 253/840 - (30%)

  Fly     2 YGTGKDRSGQEIISPQDYPVQQQRAQSKSEYVMNSASVDRPQQQSRPQPTQDYVPFESSDSSVER 66
            :.|.:|.:|       ||.:.|.:          ...:|...::|.|||..|       |.:
Mouse     8 FDTMEDHAG-------DYTLLQDQ----------EGDMDHGLKESPPQPPAD-------DGA--- 45

  Fly    67 KKEQPSAQLSTDYTNSNTTSD-SASYGSDSVSKQQIRSQQNPEYQN--NAYEAPRDDRSQLQPQR 128
              |:|.::.| |..::.|..| :|....:....:|..:|.:.|...  .|.||...|    .|.:
Mouse    46 --EEPGSETS-DAKSTPTAEDVTAPLVDERAPDKQAAAQPHTEIPEGITAEEAGIGD----TPNQ 103

  Fly   129 SQPATDYSAYERQ------------------QRPPPTTLDYT----TGYNAPPKDRTTLSRTNSR 171
            ...|..:...|.:                  |.|...|.|:|    :..:..|.....|.....:
Mouse   104 EDQAAGHVTQEPEKVEIFSQSLLVEPGRREGQAPDLGTSDWTRQQVSSMSGAPLLPQGLREATCQ 168

  Fly   172 PTLSSPNPKLQSIPNTEYVR--PPQ------------------------NFVLPP---QMRPAVG 207
            |:.:.|....:|.|.:|.:|  |||                        :...||   .:.|...
Mouse   169 PSGTRPEDIEKSHPASELLRRGPPQKEGWGQDRLGSEEEVDEDLTVDESSQDSPPSQASLTPGRA 233

  Fly   208 PPQPRPPFAGARPMVGMGPRPPMPPNMAARPPPLR-----STDSKSNLLMGP---PMRPG----- 259
            .||     ||:..:.|.....|..|...:.|.|..     |.:::::...||   ||..|
Mouse   234 APQ-----AGSGSVCGETASVPGLPTEGSVPLPADFFSKVSAETQASQPEGPGTGPMEEGHEAAP 293

  Fly   260 -----------MPPQLNMQQARLPNA-GGQLSPPGQGP-----------PRPPGGFPWNPAGAPG 301
                       .|.:.:::.|.:... |.:.....|||           ..|||..|  .||.||
Mouse   294 EFTFHVEIKASTPKEQDLEGATVVGVPGEEQKAQTQGPSVGKGTKEASLQEPPGKQP--AAGLPG 356

  Fly   302 MPPGARPPQ---------------NMTRPPPPTFARPPPGQPLQAPFNRPPF---------NQPP 342
            .|. :|.||               ...:...|:.|:.|..:|..:| .||..         :.|.
Mouse   357 RPV-SRVPQLKARVASKDRTGNDEKKAKTSTPSCAKAPSHRPCLSP-TRPTLGSSDPLIKPSSPA 419

  Fly   343 MQPQQQQPPQQLQQQQQQQQQQQHMQQQQQLR------------PLSAASAHNNNDDDDDVVMGP 395
            :.|:....|:.:.....:.....  .:|.:|:            |..|||.......:...:
Mouse   420 VCPEPATSPKHVSSVTPRNGSPG--TKQMKLKGADGKTGAKIATPRGAASPAQKGTSNATRI--- 479

  Fly   396 AVTPLKTFNSRPDPMGEPLLEDIEPPFQTSPPAG-ESKKGPGFKGDNDSGVDESTQEKDRNGPNS 459
               |.||..|...|.|..    .:.|.:..|||| :|::|            |..:..:|:|.:|
Mouse   480 ---PAKTTPSPKTPPGSA----SKQPQRKLPPAGAKSERG------------EPPKSGERSGYSS 525

  Fly   460 PSSPVKTPTSTSSKPDKSGTSRPPSATPSN----KSAPKSRSASKNRLLLKTPEPEPVKKVPMNK 520
            |.|| .||.|.|..|   ....||:..|..    ::.|||.||||:||
Mouse   526 PGSP-GTPGSRSRTP---SLPTPPTREPKKVAVVRTPPKSPSASKSRL----------------- 569

  Fly   521 VQVGHAPSPNLKAVRSKIGSLDNATYKPGGGHVKIESKKIDIKAAPRIEAKNDKYMPKGGEKKIV 585
             |....|.|:||.|||||||.:|..::||||.|:|.:||:|:.
Mouse   570 -QTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLS---------------------- 611

  Fly   586 TTKLQWNAKSKIGSLENAAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGDIKIQTQK 650
                  |.:||.||.:|..|.||||..:|....:|. .|...|.||..|:.|:||||.::::::|
Mouse   612 ------NVQSKCGSKDNIKHVPGGGSVQIVYKPVDL-SKVTSKCGSLGNIHHKPGGGQVEVKSEK 669

  Fly   651 LEIK--AQSKVGSLDNVKHKPGGGEKKIFDDKDYLKNVEHSVALTTPPTQSPLPSMTASG 708
            |:.|  .|||:|||||:.|.||||.|||...|  |...|::.|.|....:....|...||
Mouse   670 LDFKDRVQSKIGSLDNITHVPGGGNKKIETHK--LTFRENAKAKTDHGAEIVYKSPVVSG 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	PHA03247	<113..529	CDD:223021	114/543 (21%)
		Tubulin-binding	521..551	CDD:459807	15/29 (52%)
		Tubulin-binding	582..610	CDD:459807	9/27 (33%)
		Tubulin-binding	612..642	CDD:459807	10/29 (34%)
		Tubulin-binding	644..672	CDD:459807	14/29 (48%)
Mapt	XP_036012271.1	LGT	<41..211	CDD:469786	35/186 (19%)
		PHA03247	<345..580	CDD:223021	68/284 (24%)
		Tubulin-binding	<578..599	CDD:459807	12/20 (60%)
		Tubulin-binding	601..630	CDD:459807	14/56 (25%)
		Tubulin-binding	632..661	CDD:459807	10/29 (34%)
		Tubulin-binding	663..693	CDD:459807	14/29 (48%)