DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tau and Map4

DIOPT Version :9

Sequence 1:	NP_733224.2	Gene:	tau / 326116	FlyBaseID:	FBgn0266579	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_006512018.1	Gene:	Map4 / 17758	MGIID:	97178	Length:	1126	Species:	Mus musculus

Alignment Length:	791	Identity:	201/791 - (25%)
Similarity:	297/791 - (37%)	Gaps:	243/791 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DRSGQEIISPQDYPVQQQRAQSKSEYVMN-------------SASVDRPQQQSRPQPTQDYVPFE 58
            |.|..||      ||.|:...|::|.|:.             :..|..|.:..||..| |..|..
Mouse   393 DESSAEI------PVAQETVVSETEVVLATEVVLPSDPITTLTKDVTLPLEAERPLVT-DMTPSL 450

  Fly    59 SSDSSVERKKEQPSAQLSTDYTNSNTTSD-------SASYGSDSV----------------SKQQ 100
            .::.::.::...|:.      ||.....|       ..:.|.|.|                |:::
Mouse   451 ETEMTLGKETAPPTE------TNLGMAKDMSPLPESEVTLGKDVVILPETKVAEFNNVTPLSEEE 509

  Fly   101 IRS--QQNPEYQNNAYEAPRDDRSQLQ-------PQRSQPATDYSAYERQQRPPPTTLDYTTGYN 156
            :.|  ..:|..:.   |||....:.|.       .....||:|.:.        |......|
Mouse   510 VTSVKDMSPSAET---EAPLAKNADLHSGTELIVDNSMAPASDLAL--------PLETKVAT--- 560

  Fly   157 APPKDRTTLS-----RTNSR-------------PTLSSPNP-----KLQSIPNTEYVRPPQNFVL 198
            .|.||:.|:.     |.:|:             |..:||.|     ::.::| .:...|.:|.
Mouse   561 VPIKDKGTVQTEEKPREDSQLASMQHKGQSTVPPCTASPEPVKAAEQMSTLP-IDAPSPLENL-- 622

  Fly   199 PPQMRPAVGPPQPRPPFAG------ARPMVGM-GPRPPMPPNMAARPPPLRSTDSKSNLLMGPPM 256
              :.:...| .||..|.:|      |:..||: |.....|||  ..|||  |.:.|:.     |:
Mouse   623 --EQKETPG-SQPSEPCSGVSRQEEAKAAVGVTGNDITTPPN--KEPPP--SPEKKAK-----PL 675

  Fly   257 RPGMPPQLNMQQARLPNAGGQLSPPGQGPPRPPGGFPWNP--------AGAPGMPPG-----ARP 308
            ....|.:.:..:|:..    ..|.|.|..|...||....|        ..||...|.     |||
Mouse   676 ATTQPAKTSTSKAKTQ----PTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARP 736

  Fly   309 ---PQNMTRPPPPTFA-----RPPPGQPLQAPFNRP-PFNQPPMQPQQQQPPQQLQQQQQQQQQQ 364
               |....:|.|.|.|     |..|.:|..||..:| |...|.:  .:...|..|
Mouse   737 STLPARDVKPKPITEAKVAEKRTSPSKPSSAPALKPGPKTTPTV--SKATSPSTL---------- 789

  Fly   365 QHMQQQQQLRPLSAASAHNNNDDDDDVVMGPAV-TPLKTFNSRPDPM---GEPLLEDIEPPFQTS 425
                                      |..||:. :|..|...||..:   |:|  .|::.....|
Mouse   790 --------------------------VSTGPSSRSPATTLPKRPTSIKTEGKP--ADVKRMTAKS 826

  Fly   426 PPAGESKKGPGFKGDNDSGVDESTQEKDRNGPNSPSSPVKTPTSTSSKPDKS----GTSRPPSAT 486
            ..|..|:.    |..:.|.|..:|..   .|...|:....|.....|.|.:|    ...:.|::|
Mouse   827 ASADLSRS----KTTSASSVKRNTTP---TGAAPPAGMTSTRVKPMSAPSRSSGALSVDKKPTST 884

  Fly   487 PSNKSAPK-SRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAPSPNLKAVRSKIGSLDNATYKPGG 550
            ..:.|||: ||.|:.                         ..:|:||:||||:||.:|..::|||
Mouse   885 KPSSSAPRVSRLATT-------------------------VSAPDLKSVRSKVGSTENIKHQPGG 924

  Fly   551 GHVKIESK------------KIDIKAAPRIEAKNDKYMPKGGEKKIVTTKLQW-NAKSKIGSLEN 602
            |..|:|.|            ....|||..|.:..   .|..|:.:||:.|:.: :.:||.||.:|
Mouse   925 GRAKVEKKTEAATTAGKPEPNAVTKAAGSIASAQ---KPPAGKVQIVSKKVSYSHIQSKCGSKDN 986

  Fly   603 AAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGDIKIQTQKLEI--KAQSKVGSLDNV 665
            ..|.||||:.:|:..|:|. .|...|.||.||:||:|||||:||::|||..  |||:||||||||
Mouse   987 IKHVPGGGNVQIQNKKVDI-SKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNV 1050

  Fly   666 KHKPGGGEKKI 676
            .|.|.||..|:
Mouse  1051 GHLPAGGAVKV 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	Tubulin-binding	521..551	CDD:278828	12/29 (41%)
		Tubulin-binding	583..610	CDD:278828	11/27 (41%)
		Tubulin-binding	613..642	CDD:278828	13/28 (46%)
		Tubulin-binding	644..672	CDD:278828	18/29 (62%)
Map4	XP_006512018.1	PHA03247	<593..903	CDD:223021	86/400 (22%)
		Tubulin-binding	<904..925	CDD:366087	11/20 (55%)
		Tubulin-binding	965..994	CDD:366087	11/28 (39%)
		Tubulin-binding	996..1025	CDD:366087	13/29 (45%)
		Tubulin-binding	1027..1057	CDD:366087	18/29 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4402
Isobase	1	0.950	-	0	Normalized mean entropy	S5326
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43214
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.000