DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tau and Map2

DIOPT Version :9

Sequence 1:	NP_733224.2	Gene:	tau / 326116	FlyBaseID:	FBgn0266579	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_036018500.1	Gene:	Map2 / 17756	MGIID:	97175	Length:	1910	Species:	Mus musculus

Alignment Length:	764	Identity:	167/764 - (21%)
Similarity:	270/764 - (35%)	Gaps:	268/764 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QEIIS-PQDYPVQQQRAQSKSEYVMNSASVDRPQQQSRPQPTQDYVPFESSDSSVE------RKK 68
            :.|:| |.:.|.:::..::..||       |:...:|......|.:..||.:..||      :..
Mouse  1311 EAIVSEPAEVPSEEEEIEAGGEY-------DKLLFRSDTLQISDLLVSESREEFVETCPGELKGV 1368

  Fly    69 EQPSAQLSTDY-TNSNTTSDSASYGSDSV---SKQQIRSQQNPEYQNNAYEAPRDDRSQLQPQRS 129
            .:....:..|: |...||:|....||.||   :..|...::.|...:...|......:|.:|:..
Mouse  1369 VESVVTIEDDFITVVQTTTDEGESGSHSVRFAAPAQPEEERRPRPHDEELEIEMAAEAQAEPKDG 1433

  Fly   130 Q---PATD------YSAYERQQRPPPTTLDYTTGYNAPPKDRTTL-------------SRTNSRP 172
            .   |||.      :|.|:.:     |..||        ||.||:             ::.:.|.
Mouse  1434 SPDAPATPEKEEVAFSEYKTE-----TYDDY--------KDETTIDDSIMDADSLWVDTQDDDRS 1485

  Fly   173 TLSSPNPKLQSIPNTEYVRPPQNFVLPPQMRPAVGPPQPRPPFAGARPMVGMGPRPPMPPNMAAR 237
            .|:.   :|::||..|.......       ||::...:...||...|..:....|     .:|.:
Mouse  1486 ILTE---QLETIPKEERAEKDAR-------RPSLEKHRKEKPFKTGRGRISTPER-----KVAKK 1535

  Fly   238 PPPLRSTD---------------SKS---------NLLMGPPMRPGMPPQLNMQQARLPNAGGQL 278
            .|...|.|               .||         .|::.|.::...|..|:..:.:...|.|.|
Mouse  1536 EPSTVSRDEVRRKKAVYKKAELAKKSEVQAHSPSRKLILKPAIKYTRPTHLSCVKRKTTAASGDL 1600

  Fly   279 SPPGQGPPRPPGGFPWNPAGAPGMPPG-ARPPQNMTRPPPPTFARPPPGQPLQAPFNRPPFNQPP 342
            :       :.||.|   ......:..| ::.|:..:..|.|:...||
Mouse  1601 A-------QAPGAF---KQAKDKVTDGISKSPEKRSSLPRPSSILPP------------------ 1637

  Fly   343 MQPQQQQPPQQLQQQQQQQQQQQHMQQQQQLRPLSAASAHNNNDDDDDVVMGPAVTPLKTFNSRP 407
                                          .|.:|.....|:...:..:           .::|.
Mouse  1638 ------------------------------RRGVSGDREENSFSLNSSI-----------SSARR 1661

  Fly   408 DPMGEPLLEDIEPPFQTSPPAGESKKGPGFKGDNDSGVDESTQEKDRNGPNSPSSPVKTPTSTSS 472
            ....||:..           ||:|                        |.::|::|..|..:..:
Mouse  1662 TTRSEPIRR-----------AGKS------------------------GTSTPTTPGSTAITPGT 1691

  Fly   473 KPDKSGTSRPPSATPSNKSAPKSRSASKNRLL---------LKTPEPEPVKKVPMNKVQVGHAPS 528
            .|  |.:||.| .||...|.|::....|:.:|         ::||...|...   .::::.:.|.
Mouse  1692 PP--SYSSRTP-GTPGTPSYPRTPGTPKSGILVPSEKKVAIIRTPPKSPATP---KQLRLINQPL 1750

  Fly   529 PNLKAVRSKIGSLDNATYKPGGGHVKIESKKIDIKAAPRIEAKNDKYMPKGGEKKIVTTKLQWNA 593
            |:||.|:|||||.||..|:|.||.|:|.:||||:.                            :.
Mouse  1751 PDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLS----------------------------HV 1787

  Fly   594 KSKIGSLENAAHKPGGGDKKIETLKMDFKDKAKPKVGSTANVKHQPGGGDIKIQTQKLEIKAQSK 658
            .||.|||:|..|:||||..|||::|:|||:||:.||||..|..|.||||::||.:|||..:..:|
Mouse  1788 TSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAK 1852

  Fly   659 VGSLDNVKHKPGGGEKKIFDDKDYLKNVEHSVALTTPPTQSPLPSMTAS 707
            .                         .|:|...:.   ||||..|..||
Mouse  1853 A-------------------------RVDHGAEII---TQSPSRSSVAS 1873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	Tubulin-binding	521..551	CDD:278828	14/29 (48%)
		Tubulin-binding	583..610	CDD:278828	9/26 (35%)
		Tubulin-binding	613..642	CDD:278828	17/28 (61%)
		Tubulin-binding	644..672	CDD:278828	6/27 (22%)
Map2	XP_036018500.1	MAP2_projctn	458..1592	CDD:369841	61/315 (19%)
		Tubulin-binding	1747..1774	CDD:395337	15/26 (58%)
		Tubulin-binding	1775..1805	CDD:395337	16/57 (28%)
		Tubulin-binding	1806..1837	CDD:395337	18/30 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43214
orthoMCL	1	0.900	-	-		OOG6_106583
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8371
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930