Protein Alignment tau and FAM47E

DIOPT Version :10

• Sequence 1: NP_733224.2
• Gene: tau / 326116
• FlyBaseID: FBgn0266579
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001130042.1
• Gene: FAM47E / 100129583
• HGNCID: 34343
• Length: 393
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 57/329 - (17%)
• Similarity: 106/329 - (32%)
• Gaps: 83/329 - (25%)

  Fly   452 KDRNGPNSPSSPVKTPTSTSSK----------------PDKSGT--------------SRPPSAT 486
            |.:||       :|.|||..|:                |..:|.              .|.|...
Human    29 KHKNG-------LKFPTSLHSRQLVFPRKGLDDFRKGCPPCTGLVTQVPVEGFLPQIYHRAPQLA 86

  Fly   487 PSNKSAPKSRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAPSP-----NLK-----AVRSKIGSL 541
            |..:.....:.|.   :|.|....:..:|..:..|:....|.|     ||:     .:.||:..:
Human    87 PKKRQIKLLKEAD---VLSKLSPAQQARKAFLEDVEAHLTPHPLALYLNLEEAMPIELLSKVLEV 148

  Fly   542 DNATYKPGGGHVKIESKKIDIKAAPRIEAKNDKYMPKGGEKKI-VTTKLQW---NAKSKIGSLEN 602
            .:...|........:..:..:|...::..|:...:..|..||. |:...||   ....|:..|..
Human   149 LDPDRKLEDTWAYCQDTRKGMKEPTKLLKKHSTQVYLGPSKKTSVSNAGQWLYEEKPHKMDLLHE 213

  Fly   603 AAHKPGGGDKKIETL-------KMDFKDKAKPKVGSTANVKHQPGGGDIKIQTQKLEIKAQSKVG 660
            ...:||..:..|..:       :.|...:.||    :.:..|     .:|:....||:|....:.
Human   214 NGPRPGLHENGISDIDEEFILKQFDIDYETKP----SHDALH-----TMKLNQVPLELKRSVGLS 269

  Fly   661 SLDNVK-HKPGGGEKKIFDDKDYLK----NVEHSVALTTPP------TQSPL--PSMTASGADEN 712
            .|...: .:..|.|:|:...::..|    .:.:......|.      ...||  |.::....:||
Human   270 KLQETEFFQKLGYERKLQKPQNPYKPKWVKMRYGAWYLNPKLWKKQRVDEPLVDPEVSHKAQEEN 334

  Fly   713 LNQQ 716
            ..::
Human   335 FKKE 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tau	NP_733224.2	PHA03247	<113..529	CDD:223021	19/106 (18%)
		Tubulin-binding	521..551	CDD:459807	8/39 (21%)
		Tubulin-binding	582..610	CDD:459807	9/31 (29%)
		Tubulin-binding	612..642	CDD:459807	5/36 (14%)
		Tubulin-binding	644..672	CDD:459807	5/28 (18%)
FAM47E	NP_001130042.1	FAM47	1..>174	CDD:405345	26/154 (17%)