DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Atg16 and SNRNP40

DIOPT Version :9

Sequence 1:NP_001138124.2 Gene:Atg16 / 326115 FlyBaseID:FBgn0039705 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_004805.2 Gene:SNRNP40 / 9410 HGNCID:30857 Length:357 Species:Homo sapiens


Alignment Length:317 Identity:92/317 - (29%)
Similarity:148/317 - (46%) Gaps:27/317 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 GYLGQANPTKI------LMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVL 366
            |.|.||.|.:.      :|....||.|.:..::.|....:|:.|.||.:.||:: ....:..|.|
Human    42 GALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATL 105

  Fly   367 SGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQE-PIKVVTG 430
            .|.|..:..:.:::.|:.:...|.|....||..........|.||:..|.:....:. |..|.||
Human   106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170

  Fly   431 SHDRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEK-------Q 488
            |.|.|:|:||:|..|.|:| |..:.....||.:.....||||..|..|:.||:|..|       .
Human   171 SDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGH 234

  Fly   489 ADDVLMPAKITSLDLSKDCNYLICSVRDDTIKLLDLR----KNQVISTFTNEHFKISCDFARASF 549
            ||.|      |.|.||.:.:||:.:..|:|:::.|:|    |.:.:..|.........:..|.|:
Human   235 ADSV------TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293

  Fly   550 NSSGLKIACGSADGAIYIWNVNG-FLEATLKGHSTAVNAVSWSPNNNMLASVGKNKR 605
            :..|.|||.||||..:|:|:... .:...|.||:.::|.|::.|:..::.|...:||
Human   294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKR 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg16NP_001138124.2 ATG16 11..197 CDD:285778
SynN 120..229 CDD:294095
WD40 322..605 CDD:238121 84/295 (28%)
WD40 repeat 331..368 CDD:293791 9/36 (25%)
WD40 <341..612 CDD:225201 82/278 (29%)
WD40 repeat 374..410 CDD:293791 6/35 (17%)
WD40 repeat 415..453 CDD:293791 16/38 (42%)
WD40 repeat 461..491 CDD:293791 12/36 (33%)
WD40 repeat 498..536 CDD:293791 12/41 (29%)
WD40 repeat 544..579 CDD:293791 12/35 (34%)
WD40 repeat 585..609 CDD:293791 6/21 (29%)
SNRNP40NP_004805.2 WD40 62..351 CDD:238121 86/297 (29%)
WD 1 64..103 10/39 (26%)
WD40 repeat 70..107 CDD:293791 9/37 (24%)
WD 2 107..146 7/38 (18%)
WD40 repeat 112..148 CDD:293791 5/35 (14%)
WD 3 149..189 16/39 (41%)
WD40 repeat 155..190 CDD:293791 14/35 (40%)
WD 4 191..230 12/38 (32%)
WD40 repeat 196..232 CDD:293791 12/35 (34%)
WD 5 233..272 14/44 (32%)
WD40 repeat 238..278 CDD:293791 12/45 (27%)
WD 6 283..322 12/38 (32%)
WD40 repeat 288..312 CDD:293791 11/23 (48%)
WD 7 325..357 8/26 (31%)
WD40 repeat 330..352 CDD:293791 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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