DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg16 and ATG16L2

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_203746.1	Gene:	ATG16L2 / 89849	HGNCID:	25464	Length:	619	Species:	Homo sapiens

Alignment Length:	654	Identity:	194/654 - (29%)
Similarity:	305/654 - (46%)	Gaps:	101/654 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WRAHVVRRLRERNRKECDNFKEIIEQNNRLIDHVAQLKADNL-KISVENEQLRNAVSTGGTGSNV 71
            |:.|:||:||.|:|.:...|.|::...|.|::     ||:.| |.|
Human    14 WKRHIVRQLRLRDRTQKALFLELVPAYNHLLE-----KAELLDKFS------------------- 54

  Fly    72 AIATLEKKLLSQQEELT-ELHKRKGENSQM-------IVDLNQKVEQQ----RIIISEKEHSLVE 124
                  |||..:...:| ..|:...|.|::       :|.|..|.:::    |::..|..:.:||
Human    55 ------KKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVE 113

  Fly   125 QQTNNNRLRAEVQLLHSSL---------------------EELKKLNNTMLDEHTALQLAFSSLE 168
            :......|.:|:|...|.|                     ||.:..|......:.||:......|
Human   114 KGAALGTLESELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLRE 178

  Fly   169 EKLRGVQDENRRLLERLMQYKSKDADKLNEENESIIRKRLPSIFRKRSAKLKRDLEDAVREPSSS 233
            ..||.:|:|.|.|||||:|.|::.|.:.|..||   |:.     |.:.|::.::|:.|.:...|.
Human   179 AALRRLQEEARDLLERLVQRKARAAAERNLRNE---RRE-----RAKQARVSQELKKAAKRTVSI 235

  Fly   234 SNAASSPGAASLQRNSSPAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSR 298
            |....:.|....:|..:.|      :..|  .|.....|.|..........:...|.....:..:
Human   236 SEGPDTLGDGMRERRETLA------LAPE--PEPLEKEACEKWKRPFRSASATSLTLSHCVDVVK 292

  Fly   299 ASIDTLKATGY-LGQAN---------------PTKILMKFEAHENESHAVRWSPVERMVATGGAD 347
            ..:|..|..|: :|.|.               ||:.....:||.:|.:|||:.|...::||||||
Human   293 GLLDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGAD 357

  Fly   348 RKVKLWDIGKNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHS 412
            |.:.||::..:..|....|.|:...|.|||||.:|..:|..:.:..|::|.|.:.:.:.||:||.
Human   358 RLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHK 422

  Fly   413 GKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKK 477
            .||.|||:.....:.||||.|||:|.|||....|..|....|.|||:|..|.:   |||||.|:|
Human   423 DKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHI---IISGHNDQK 484

  Fly   478 IRFWDIRTEKQADDVLMPAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISC 542
            |||||.|.......:.:..::|||.||.|..:|:...||:|:|::|||.:.:...|..:.||...
Human   485 IRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGS 549

  Fly   543 DFARASFNSSGLKIACGSADGAIYIWNVN-GFLEATLKG-HSTAVNAVSWSPNNNMLASVGKNKR 605
            |:.:|.|:........||.|||:|||:|: |.||:.|:| |..|||||:|..:.:.:.||.:.::
Human   550 DWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRK 614

  Fly   606 CTIY 609
            ..::
Human   615 VVLW 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778	54/219 (25%)
		SynN	120..229	CDD:294095	34/129 (26%)
		WD40	322..605	CDD:238121	114/284 (40%)
		WD40 repeat	331..368	CDD:293791	15/36 (42%)
		WD40	<341..612	CDD:225201	107/271 (39%)
		WD40 repeat	374..410	CDD:293791	12/35 (34%)
		WD40 repeat	415..453	CDD:293791	17/37 (46%)
		WD40 repeat	461..491	CDD:293791	14/29 (48%)
		WD40 repeat	498..536	CDD:293791	15/37 (41%)
		WD40 repeat	544..579	CDD:293791	14/35 (40%)
		WD40 repeat	585..609	CDD:293791	7/23 (30%)
ATG16L2	NP_203746.1	ATG16	17..203	CDD:285778	53/215 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..78		5/20 (25%)
		FliJ	86..190	CDD:280262	22/103 (21%)
		WD40	324..>619	CDD:225201	116/298 (39%)
		WD40	331..619	CDD:238121	114/291 (39%)
		WD 1. /evidence=ECO:0000255	334..373		17/38 (45%)
		WD40 repeat	341..378	CDD:293791	15/36 (42%)
		WD 2. /evidence=ECO:0000255	378..417		12/38 (32%)
		WD40 repeat	384..420	CDD:293791	12/35 (34%)
		WD 3. /evidence=ECO:0000255	420..454		18/33 (55%)
		WD40 repeat	425..461	CDD:293791	17/35 (49%)
		WD 4. /evidence=ECO:0000255	455..498		21/45 (47%)
		WD40 repeat	467..499	CDD:293791	17/34 (50%)
		WD 5. /evidence=ECO:0000255	500..539		14/38 (37%)
		WD40 repeat	505..543	CDD:293791	15/37 (41%)
		WD 6. /evidence=ECO:0000255	546..585		16/38 (42%)
		WD40 repeat	551..587	CDD:293791	14/35 (40%)
		WD 7. /evidence=ECO:0000255	589..619		9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0288
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2377
SonicParanoid	1	1.000	-	-		X1444
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.840