DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg16 and MDV1

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_012423.1	Gene:	MDV1 / 853332	SGDID:	S000003648	Length:	714	Species:	Saccharomyces cerevisiae

Alignment Length:	608	Identity:	137/608 - (22%)
Similarity:	229/608 - (37%)	Gaps:	133/608 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KISVENEQLRNAVSTGGTGSNVAIATLEKKLLSQQEELTELHKRKGENSQMIVDLNQKVEQQRII 114
            ::::||.:..| ..|.||...|.    .|.::|:..|..|:|... .|.|....:...||.::|
Yeast   160 ELAIENTERLN-YDTNGTSGTVG----AKDVMSKTNERDEIHTEL-PNFQDSFLIPPGVETKKI- 217

  Fly   115 ISEKEHSLVEQQTNNNRLRAEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENR 179
                     ....:.:.|::..|.|.:|||.|....|:.|.|              :|.::.|
Yeast   218 ---------SSSYSPSALKSFSQTLVNSLEFLNIQKNSTLSE--------------IRDIEVE-- 257

  Fly   180 RLLERLMQYKSKDADKLN--EENESIIRKRLPSIFRKRSAKLKRDLEDAVREPSSSSNAASSPGA 242
              :|.|.|.|.|...|:.  |:|:.::...|..|..:.....:..||  |.|.:|..| |...|.
Yeast   258 --VENLRQKKEKLLGKIANIEQNQLLLEDNLKQIDDRLDFLEEYGLE--VIEANSDEN-AEDDGM 317

  Fly   243 ASLQRNSSPAQFVGGLIGDEDFDEAAINGAMEAIGL---------DDNEY--ISARFTAGEIAEN 296
            :..:...:.|      |.:|.....:|:.  ||..|         |||..  :.|.::..:  :.
Yeast   318 SERKALKNDA------IRNEGVTTESISS--EASNLPPRRRQQLRDDNSLNRLGAFYSKSK--KR 372

  Fly   297 SRASIDTLKATGYLGQANPTKILMKFEAHENESHAVRW-SPVERMVATGGADRKVKLWDIGKNST 360
            .|.|..|.:.....|    |||......|::....:.: :|...:...|..|..||:||:.|.:
Yeast   373 HRKSFPTFQQLYEPG----TKIGSIMSTHDDFLTCLDFDAPFGTLCTAGYLDHTVKIWDLSKQN- 432

  Fly   361 EPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTV-------------------MDNRLRH 406
             ....|:|..|.||.:..:.....::....|...::|.:                   :|:...|
Yeast   433 -KIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNLAQQLYQETQNLTSPTNHIDSPCVH 496

  Fly   407 TLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIET---KFAGSSCNDLVTT------ 462
            |...|:.:|.|...  :|..:|:||.|||::.|||||..|::|   .||    |.|.|:
Yeast   497 TFEAHTDEVTALSL--DPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSFA----NVLTTSTNVDLS 555

  Fly   463 -----------------DSLGSTIISGHYDKKIRFWDIRTEKQADDVLMPAK-----ITSLDLSK 505
                             .|..:.:.:|..|..:|.||:|:.|    |:...|     ||||....
Yeast   556 KSTLLTQRNERPSIGALQSFDAALATGTKDGVVRLWDLRSGK----VIRTLKGHTDAITSLKFDS 616

  Fly   506 DCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSADGAIYIWNV 570
            .|  |:....|.|:::.|||...:..........:|.|.    |..:...:........||....
Yeast   617 AC--LVTGSYDRTVRIWDLRTGLLNKFHAYSAPVLSLDL----FQENAAVVVADEPSVQIYDSEK 675

  Fly   571 NGFLEATLKGHSTAVNAVSWSPN 593
            :.......:|:.|:|:.|.:..|
Yeast   676 DESWSCVEQGNETSVSTVKYKEN 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778	35/146 (24%)
		SynN	120..229	CDD:294095	25/110 (23%)
		WD40	322..605	CDD:238121	72/323 (22%)
		WD40 repeat	331..368	CDD:293791	9/37 (24%)
		WD40	<341..612	CDD:225201	70/303 (23%)
		WD40 repeat	374..410	CDD:293791	6/54 (11%)
		WD40 repeat	415..453	CDD:293791	17/40 (43%)
		WD40 repeat	461..491	CDD:293791	9/52 (17%)
		WD40 repeat	498..536	CDD:293791	11/37 (30%)
		WD40 repeat	544..579	CDD:293791	3/34 (9%)
		WD40 repeat	585..609	CDD:293791	3/9 (33%)
MDV1	NP_012423.1	Mdv1	123..171	CDD:402923	3/11 (27%)
		WD40	397..713	CDD:238121	72/320 (23%)
		WD40 repeat	402..439	CDD:293791	9/38 (24%)
		WD40 repeat	444..499	CDD:293791	7/54 (13%)
		WD40 repeat	506..539	CDD:293791	15/34 (44%)
		WD40 repeat	546..603	CDD:293791	11/60 (18%)
		WD40 repeat	648..683	CDD:293791	5/38 (13%)
		WD40 repeat	690..712	CDD:293791	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	70	1.000	Inparanoid score	I1695
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1444
TreeFam	0	0.000	Not matched by this tool.
	2	2.050