DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg16 and AT5G50230

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_199834.2	Gene:	AT5G50230 / 835088	AraportID:	AT5G50230	Length:	509	Species:	Arabidopsis thaliana

Alignment Length:	554	Identity:	142/554 - (25%)
Similarity:	245/554 - (44%)	Gaps:	105/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 AIATLEKKLLSQ-----------QEELTELHKRKGENSQMIVDLNQKVEQQRIIISEKEHSLVEQ 125
            ||:.|.|.|:||           :.||.:.:|.:...|:.:|....:....:.|:.|||..:.:.
plant    32 AISALSKPLISQGSEWKEKTEKLETELQQCYKAQSRLSEQLVIEVAESRTSKAILQEKELLINDL 96

  Fly   126 QTNNNRLRAEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERLMQYKS 190
            |....:.|.:...|...|||..|..:.::.|:..::.....:..:::..:.||:.|::|.|..|.
plant    97 QKELTQRREDCTRLQEELEEKTKTVDVLIAENLEIRSQLEEMTSRVQKAETENKMLIDRWMLQKM 161

  Fly   191 KDADKLNEENESIIRKRLPSIFRKRSAKLKRDLEDAVREPSSSSNAASSPGAASLQRNSSPAQFV 255
            :||::|||.|:         ::.:..||||.:                  |..:|.|     |.|
plant   162 QDAERLNEAND---------LYEEMLAKLKAN------------------GLETLAR-----QQV 194

  Fly   256 GGLI-----GDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRASIDTLKATGYLGQANP 315
            .|::     |.:.|.|:.|                                             |
plant   195 DGIVRRNEDGTDHFVESTI---------------------------------------------P 214

  Fly   316 TKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLSGSSAGINSVDFDS 380
            :....:..|||....::.:......:.|||.||.||:||  .||......|.||...|..:....
plant   215 STCANRIHAHEGGCGSIVFEYNSGTLFTGGQDRAVKMWD--TNSGTLIKSLYGSLGNILDMAVTH 277

  Fly   381 TGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMA---AKYVQEPIKVVTGSHDRTLKIWDLR 442
            ....::..::.....||.|...|:|||||||:.||.|   :|:...  .||:.::|||:|:|||.
plant   278 DNKSVIAATSSNNLFVWDVSSGRVRHTLTGHTDKVCAVDVSKFSSR--HVVSAAYDRTIKLWDLH 340

  Fly   443 SIACIETKFAGSSCNDL-VTTDSLGSTIISGHYDKKIRFWDIRTEKQADDVL-MPAKITSLDLSK 505
            ...|..|....|:||.: ::.|  |.|:.|||.|..:|.|||:|.|...:|. ..:.:||:.||:
plant   341 KGYCTNTVLFTSNCNAICLSID--GLTVFSGHMDGNLRLWDIQTGKLLSEVAGHSSAVTSVSLSR 403

  Fly   506 DCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSADGAIYIWNV 570
            :.|.::.|.||:...:.|.|..::..|......:::.:::|:..:.....:|.|||||::::|::
plant   404 NGNRILTSGRDNVHNVFDTRTLEICGTLRASGNRLASNWSRSCISPDDDYVAAGSADGSVHVWSL 468

  Fly   571 N-GFLEATLKGHSTAVNAVSWSPNNNMLASVGKN 603
            : |.:.:.||..::.:...|||.....|||..||
plant   469 SKGNIVSILKEQTSPILCCSWSGIGKPLASADKN 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778	32/135 (24%)
		SynN	120..229	CDD:294095	24/108 (22%)
		WD40	322..605	CDD:238121	91/288 (32%)
		WD40 repeat	331..368	CDD:293791	12/36 (33%)
		WD40	<341..612	CDD:225201	88/269 (33%)
		WD40 repeat	374..410	CDD:293791	8/35 (23%)
		WD40 repeat	415..453	CDD:293791	14/40 (35%)
		WD40 repeat	461..491	CDD:293791	13/29 (45%)
		WD40 repeat	498..536	CDD:293791	11/37 (30%)
		WD40 repeat	544..579	CDD:293791	9/35 (26%)
		WD40 repeat	585..609	CDD:293791	8/19 (42%)
AT5G50230	NP_199834.2	RILP-like	<70..182	CDD:304877	27/120 (23%)
		WD40	201..508	CDD:225201	96/353 (27%)
		WD40	224..508	CDD:238121	90/285 (32%)
		WD40 repeat	271..307	CDD:293791	8/35 (23%)
		WD40 repeat	312..351	CDD:293791	14/40 (35%)
		WD40 repeat	355..390	CDD:293791	14/36 (39%)
		WD40 repeat	396..434	CDD:293791	11/37 (30%)
		WD40 repeat	442..478	CDD:293791	9/35 (26%)
		WD40 repeat	484..508	CDD:293791	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0288
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41786
Inparanoid	1	1.050	148	1.000	Inparanoid score	I1735
OMA	1	1.010	-	-		QHG53779
OrthoDB	1	1.010	-	-		D404224at2759
OrthoFinder	1	1.000	-	-		FOG0004186
OrthoInspector	1	1.000	-	-		oto3337
orthoMCL	1	0.900	-	-		OOG6_103883
Panther	1	1.100	-	-	LDO	PTHR19878
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1444
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840