DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg16 and atg16l1

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001017854.1	Gene:	atg16l1 / 550552	ZFINID:	ZDB-GENE-050417-401	Length:	330	Species:	Danio rerio

Alignment Length:	355	Identity:	104/355 - (29%)
Similarity:	180/355 - (50%)	Gaps:	61/355 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EHVWRAHVVRRLRERNRKECDNFKEIIEQNNRLID--HVAQLKADNLKISVENEQLRNAVS---T 64
            |.:|:.|||.:|::|:|.:...|:|||.|.|||::  .:..:.::.|:.....:|.|:.:|   .
Zfish     7 ECLWKRHVVEQLKQRDRVQRQAFEEIIHQYNRLLEKSDLQVVFSERLQTEKYEQQNRHDLSPCVD 71

  Fly    65 GGTGSNVAIATLEKKLLSQQEELTELHKRKGENSQMIVDLNQKVEQQRIIISEKEHSLVEQQTNN 129
            ||...::. ..:.:..:..|||||||||::||.:|.:::||.:::|:...|...|..:.|.....
Zfish    72 GGRSDSLQ-QEMSQMRIRHQEELTELHKKRGELAQSVIELNNQIQQKDKEIQSNEVKMQEYLQQI 135

  Fly   130 NRLRAEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERLMQYKSKDAD 194
            ::|..|.:.|.:.|.:|::.|.|:.||:.|||:.||:||||||...::|:.|:.|.|..|:::|:
Zfish   136 SQLEGECRELRNCLADLERANQTLRDEYDALQITFSALEEKLRKTTEDNQELVTRWMAEKAQEAN 200

  Fly   195 KLNEENESIIRKRLPSIFRKRSAKLKRDLEDAVREP------------SSSSNAASSPGAASLQR 247
            :||.|||        ...|:|.|||:::|.||.:||            :..:..|:...:.|.|.
Zfish   201 RLNAENE--------KDSRRRQAKLQKELADAAKEPLPIDPDDDIEVLTEDAGKATGETSPSRQL 257

  Fly   248 NSSPAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARF----------TAGEIAENSRASID 302
            :.:|::              .::......||.|:  ||..|          ::.|.||...|..|
Zfish   258 SRTPSK--------------RLSQPPPPAGLLDS--ISNMFGRRRSVNSFSSSPENAEVPSACAD 306

  Fly   303 TLKATGYLGQANPTKILMKFEAHENESHAV 332
            .         ..|:..|..|:||:.|.:||
Zfish   307 V---------RVPSTALHIFDAHDGEVNAV 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778	64/190 (34%)
		SynN	120..229	CDD:294095	40/108 (37%)
		WD40	322..605	CDD:238121	6/11 (55%)
		WD40 repeat	331..368	CDD:293791	2/2 (100%)
		WD40	<341..612	CDD:225201
		WD40 repeat	374..410	CDD:293791
		WD40 repeat	415..453	CDD:293791
		WD40 repeat	461..491	CDD:293791
		WD40 repeat	498..536	CDD:293791
		WD40 repeat	544..579	CDD:293791
		WD40 repeat	585..609	CDD:293791
atg16l1	NP_001017854.1	ATG16	13..203	CDD:285778	64/190 (34%)
atg16l1	NP_001017854.1	TBPIP	<91..162	CDD:284512	24/70 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577690
Domainoid	1	1.000	116	1.000	Domainoid score	I5958
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41786
Inparanoid	1	1.050	436	1.000	Inparanoid score	I1654
OMA	1	1.010	-	-		QHG53779
OrthoDB	1	1.010	-	-		D265783at33208
OrthoFinder	1	1.000	-	-		FOG0004186
OrthoInspector	1	1.000	-	-		oto40317
orthoMCL	1	0.900	-	-		OOG6_103883
Panther	1	1.100	-	-	O	PTHR19878
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1444
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910