DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atg16 and ATG16L1

DIOPT Version :9

Sequence 1:NP_001138124.2 Gene:Atg16 / 326115 FlyBaseID:FBgn0039705 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_001350671.1 Gene:ATG16L1 / 55054 HGNCID:21498 Length:624 Species:Homo sapiens


Alignment Length:636 Identity:240/636 - (37%)
Similarity:381/636 - (59%) Gaps:57/636 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 WRAHVVRRLRERNRKECDNFKEIIEQNNRLID--HVAQLKADNLKISVENEQLRNAVSTG--GTG 68
            |:.|:..:||.|:|.:...|:|||.|.|:|::  .:..:.|..|:....:...|:.:|.|  ||.
Human    13 WKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHDGTW 77

  Fly    69 SNVAIATLEKKLLSQQEELTELHKRKGENSQMIVDLNQKVEQQRIIISEKEHSLVEQQTNNNRLR 133
            ::..:..:.:..:..|||||||||::||.:|:::|||.:::::...:...|..:.|.....:.|.
Human    78 NDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDREMQMNEAKIAECLQTISDLE 142

  Fly   134 AEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERLMQYKSKDADKLNE 198
            .|...|.:.|.:|::.|.|:.||:.|||:.|::||.|||...:||:.|:.|.|..|:::|::||.
Human   143 TECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRKTTEENQELVTRWMAEKAQEANRLNA 207

  Fly   199 ENESIIRKRLPSIFRKRSAKLKRDLEDAVREP---------------SSSSNAASSP----GAAS 244
            |||        ...|:|.|:|:::|.:|.:||               :|.....:||    ..|:
Human   208 ENE--------KDSRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAISRAA 264

  Fly   245 LQRNSSPAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRAS-------ID 302
            .:|.|.||   |||          ::......||.::..:....::......|.:|       :|
Human   265 TKRLSQPA---GGL----------LDSITNIFGLSESPLLGHHSSSDAARRRSVSSFPVPQDNVD 316

  Fly   303 TLKATGYLGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLS 367
            |...:|...:. |...|..|:||:.|.:||::||..|::||||.||:||||::.....|.:..||
Human   317 THPGSGKEVRV-PATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLS 380

  Fly   368 GSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSH 432
            ||:|||.|::|||.|:|:|..|||:.:|:|||.|.|||||||||||||::||::.:..::|:|||
Human   381 GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSH 445

  Fly   433 DRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQADDVLMPAK 497
            |||||:|||||..||:|.||||||||:|.|:   ..::|||:||||||||||:|....::.:..|
Human   446 DRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFDKKIRFWDIRSESIVREMELLGK 507

  Fly   498 ITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSAD 562
            ||:|||:.:...|:...|||.:|::|||.|.:..||:...||...|:.|..|:..|..:|.|||:
Human   508 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAE 572

  Fly   563 GAIYIWNV-NGFLEATL-KGHSTAVNAVSWSPNNNMLASVGKNKRCTIYSE 611
            |::|||:| .|.:|..| |.||:::|||:|||:.:.:.||.|..:..::::
Human   573 GSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWAQ 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg16NP_001138124.2 ATG16 11..197 CDD:285778 61/189 (32%)
SynN 120..229 CDD:294095 37/108 (34%)
WD40 322..605 CDD:238121 145/284 (51%)
WD40 repeat 331..368 CDD:293791 17/36 (47%)
WD40 <341..612 CDD:225201 136/273 (50%)
WD40 repeat 374..410 CDD:293791 21/35 (60%)
WD40 repeat 415..453 CDD:293791 21/37 (57%)
WD40 repeat 461..491 CDD:293791 15/29 (52%)
WD40 repeat 498..536 CDD:293791 16/37 (43%)
WD40 repeat 544..579 CDD:293791 15/36 (42%)
WD40 repeat 585..609 CDD:293791 9/23 (39%)
ATG16L1NP_001350671.1 ATG16 31..206 CDD:312208 56/174 (32%)
WD40 <272..390 CDD:225201 41/131 (31%)
WD40 332..622 CDD:238121 146/292 (50%)
WD40 repeat 344..381 CDD:293791 17/36 (47%)
WD40 repeat 387..423 CDD:293791 21/35 (60%)
WD40 repeat 428..465 CDD:293791 20/36 (56%)
WD40 repeat 473..503 CDD:293791 16/32 (50%)
WD40 repeat 508..544 CDD:293791 15/35 (43%)
WD40 repeat 554..590 CDD:293791 14/35 (40%)
WD40 repeat 597..621 CDD:293791 9/23 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144556
Domainoid 1 1.000 109 1.000 Domainoid score I6381
eggNOG 1 0.900 - - E1_KOG0288
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41786
Inparanoid 1 1.050 411 1.000 Inparanoid score I1864
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53779
OrthoDB 1 1.010 - - D265783at33208
OrthoFinder 1 1.000 - - FOG0004186
OrthoInspector 1 1.000 - - oto91603
orthoMCL 1 0.900 - - OOG6_103883
Panther 1 1.100 - - O PTHR19878
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2377
SonicParanoid 1 1.000 - - X1444
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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