DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atg16 and atg16l1

DIOPT Version :9

Sequence 1:NP_001138124.2 Gene:Atg16 / 326115 FlyBaseID:FBgn0039705 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_001017343.1 Gene:atg16l1 / 550097 XenbaseID:XB-GENE-1011170 Length:622 Species:Xenopus tropicalis


Alignment Length:637 Identity:249/637 - (39%)
Similarity:381/637 - (59%) Gaps:61/637 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 WRAHVVRRLRERNRKECDNFKEIIEQNNRLID--HVAQLKADNLKISVENEQLRNAVSTG--GTG 68
            ||.|:.|.||.|:|::...|:|:|.|..||::  .:..:.||.|:.....:|.|:..|.|  |..
 Frog    13 WRLHISRELRRRDREQRQVFEELISQYKRLLEKSDLQSVLADKLQAEKYEQQSRHDSSPGPDGMR 77

  Fly    69 SNVAIATLEKKLLSQQEELTELHKRKGENSQMIVDLNQKVEQQRIIISEKEHSLVEQQTNNNRLR 133
            :::.:..:.:..:..|||||||||::||.:|.:::||.:::|:...|...|..:.:.......|.
 Frog    78 NDMLLQDMAQMRIKHQEELTELHKKRGELAQTVIELNNQMQQKDKEIQANEEKIAKYLQTIQDLE 142

  Fly   134 AEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERLMQYKSKDADKLNE 198
            .|.|.|.:.|:||::.|.|:.||:.|||:.|::||:|||...::|:.|:.|.|..|:::|::||.
 Frog   143 TECQDLRNKLQELERANQTLKDEYDALQITFTALEDKLRKTTEDNQELVSRWMAEKAQEANRLNA 207

  Fly   199 ENESIIRKRLPSIFRKRSAKLKRDLEDAVREPSS------------------SSNAASSPGAASL 245
            |||        ...::|.|:|:::|.:|.:||.|                  .|..|.:.|....
 Frog   208 ENE--------KDSKRRQARLQKELAEAAKEPLSFEHDDDIEVLNDNADPVGDSAGAQATGRNIS 264

  Fly   246 QRNSSPAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRASIDTLKAT--- 307
            :|||.||  ||||          ::......||.::..:|.|..:     :.|.|:::..|:   
 Frog   265 KRNSQPA--VGGL----------LDSITNIFGLSESPSLSHRSDS-----SRRRSLNSFPASPDC 312

  Fly   308 -GYLGQAN-----PTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVL 366
             ...|..|     |...:..|:||:.|.:|||:||..|::||||.||:|||||:..|..|.:..|
 Frog   313 ADTPGAGNREVRVPATAVYSFDAHDGEVNAVRFSPGSRLLATGGMDRRVKLWDVIGNKCEAKGSL 377

  Fly   367 SGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGS 431
            :||:|||.|::|||.|:|:|..|||:.:|:|||.|.|||||||||||||::||::.:..::|:||
 Frog   378 TGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGS 442

  Fly   432 HDRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQADDVLMPA 496
            ||||||:|||||..||:|.||||||||:|.|:   ..::|||:||||||||||||....::.:..
 Frog   443 HDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFDKKIRFWDIRTECIVRELELQG 504

  Fly   497 KITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSA 561
            :||:|||:.:...|:...|||.||:.|||.|.|..||:...||...|:.|..|:..|..::.|||
 Frog   505 RITALDLNPERTQLLSCSRDDLIKITDLRANAVQQTFSAPGFKCGSDWTRVIFSPDGSYVSAGSA 569

  Fly   562 DGAIYIWNV-NGFLEATL-KGHSTAVNAVSWSPNNNMLASVGKNKRCTIYSE 611
            :|.:|.||| .|.:|... |.||:::|||:|||:...:.||.|..|..::|:
 Frog   570 EGTLYFWNVLTGKVERMFSKQHSSSINAVAWSPSGTHVVSVDKGSRGVLWSD 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg16NP_001138124.2 ATG16 11..197 CDD:285778 63/189 (33%)
SynN 120..229 CDD:294095 36/108 (33%)
WD40 322..605 CDD:238121 147/284 (52%)
WD40 repeat 331..368 CDD:293791 20/36 (56%)
WD40 <341..612 CDD:225201 139/273 (51%)
WD40 repeat 374..410 CDD:293791 21/35 (60%)
WD40 repeat 415..453 CDD:293791 21/37 (57%)
WD40 repeat 461..491 CDD:293791 16/29 (55%)
WD40 repeat 498..536 CDD:293791 18/37 (49%)
WD40 repeat 544..579 CDD:293791 13/36 (36%)
WD40 repeat 585..609 CDD:293791 10/23 (43%)
atg16l1NP_001017343.1 ATG16 31..206 CDD:370001 57/174 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..78 5/18 (28%)
WIPI2-binding. /evidence=ECO:0000250|UniProtKB:Q676U5 207..230 8/30 (27%)
FIP200-binding. /evidence=ECO:0000250|UniProtKB:Q676U5 230..242 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 244..271 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..320 6/37 (16%)
WD40 333..620 CDD:238121 148/289 (51%)
WD 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221 335..374 22/38 (58%)
WD40 repeat 341..379 CDD:293791 20/37 (54%)
WD 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221 379..418 23/38 (61%)
WD40 repeat 384..420 CDD:293791 21/35 (60%)
WD 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221 421..460 24/38 (63%)
WD40 repeat 427..462 CDD:293791 19/34 (56%)
WD 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221 462..499 25/39 (64%)
WD40 repeat 467..500 CDD:293791 20/35 (57%)
WD 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221 501..540 16/38 (42%)
WD40 repeat 506..542 CDD:293791 17/35 (49%)
WD 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221 547..588 15/40 (38%)
WD40 repeat 552..576 CDD:293791 8/23 (35%)
WD 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221 590..622 13/32 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 120 1.000 Domainoid score I5709
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41786
Inparanoid 1 1.050 436 1.000 Inparanoid score I1643
OMA 1 1.010 - - QHG53779
OrthoDB 1 1.010 - - D265783at33208
OrthoFinder 1 1.000 - - FOG0004186
OrthoInspector 1 1.000 - - oto105367
Panther 1 1.100 - - O PTHR19878
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2377
SonicParanoid 1 1.000 - - X1444
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.110

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