DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atg16 and DTL

DIOPT Version :9

Sequence 1:NP_001138124.2 Gene:Atg16 / 326115 FlyBaseID:FBgn0039705 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_057532.4 Gene:DTL / 51514 HGNCID:30288 Length:730 Species:Homo sapiens


Alignment Length:327 Identity:71/327 - (21%)
Similarity:115/327 - (35%) Gaps:92/327 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   317 KILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLSGSSAGINSVDFDST 381
            |...::.||.|....:.|.|.|..:.|...|:..|.||:  .:.|......|....:.||.|...
Human    89 KCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDV--KAGELIGTCKGHQCSLKSVAFSKF 151

  Fly   382 GAYILGT-SNDYGARVWTVMDN------RLRHTLTG----------------HSGKVMAAKY-VQ 422
            ...:..| ..|....||....|      |..:.::|                .:.|.:|... .|
Human   152 EKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQ 216

  Fly   423 EPIKVV----------TGSHDRTLKIWDLRS---------IACIETKFAGSSCNDL----VTTDS 464
            :.:.||          .|:.|..:|:||||.         ||.....:.|||...|    :..||
Human   217 QSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDS 281

  Fly   465 LGSTIISGHYDKKIRFWDIRTEKQADDVLMPAKITSLDLSKDCNYLICSVRDDTIKLLDLRKNQV 529
            .|||:.:...|              |::.|              :.:..::...:.:.:..:|  
Human   282 TGSTLFANCTD--------------DNIYM--------------FNMTGLKTSPVAIFNGHQN-- 316

  Fly   530 ISTFTNEHFKISCDFARASFNSSGLKIACGSADGAIYIWNVNGFLE--ATLKGHSTAVNAVSWSP 592
             |||          :.::|.:.....:..||:|.|.|||.|:...:  ..|.|||..|.:|.|.|
Human   317 -STF----------YVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCP 370

  Fly   593 NN 594
            ::
Human   371 SD 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg16NP_001138124.2 ATG16 11..197 CDD:285778
SynN 120..229 CDD:294095
WD40 322..605 CDD:238121 70/322 (22%)
WD40 repeat 331..368 CDD:293791 9/36 (25%)
WD40 <341..612 CDD:225201 64/303 (21%)
WD40 repeat 374..410 CDD:293791 9/42 (21%)
WD40 repeat 415..453 CDD:293791 13/57 (23%)
WD40 repeat 461..491 CDD:293791 6/29 (21%)
WD40 repeat 498..536 CDD:293791 4/37 (11%)
WD40 repeat 544..579 CDD:293791 9/36 (25%)
WD40 repeat 585..609 CDD:293791 4/10 (40%)
DTLNP_057532.4 WD 1 47..89 71/327 (22%)
WD40 55..389 CDD:238121 71/327 (22%)
WD40 repeat 55..96 CDD:293791 1/6 (17%)
WD 2 96..135 12/40 (30%)
WD40 repeat 101..137 CDD:293791 9/37 (24%)
WD 3 138..178 9/39 (23%)
WD40 repeat 144..197 CDD:293791 10/52 (19%)
DDB1-binding motif 168..171 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 188..210 1/21 (5%)
Nuclear localization signal. /evidence=ECO:0000255 197..203 0/5 (0%)
WD 4 214..253 10/38 (26%)
WD40 repeat 219..312 CDD:293791 23/120 (19%)
DDB1-binding motif 243..246 2/2 (100%)
WD40 repeat 264..304 CDD:293791 12/67 (18%)
WD 5 267..308 11/68 (16%)
WD 6 313..354 13/53 (25%)
WD40 repeat 320..356 CDD:293791 9/35 (26%)
WD 7 358..398 7/15 (47%)
WD40 repeat 363..388 CDD:293791 4/10 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..443
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..498
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 599..631
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 644..703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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