DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atg16 and DCAF8

DIOPT Version :9

Sequence 1:NP_001138124.2 Gene:Atg16 / 326115 FlyBaseID:FBgn0039705 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_056541.2 Gene:DCAF8 / 50717 HGNCID:24891 Length:597 Species:Homo sapiens


Alignment Length:468 Identity:98/468 - (20%)
Similarity:161/468 - (34%) Gaps:118/468 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   233 SSNAASSPGAASLQR---NSSPAQFVGGLIGDEDFDEAAINGAMEAIGL--DD----NEYISARF 288
            ||..:|:.|...|..   :|||.:..|...|.|......:..:..::.|  ||    .....:|.
Human     2 SSKGSSTDGRTDLANGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGPNRTSTESRG 66

  Fly   289 TAGEIAENSRASIDTLKATGYLGQANPTKILMKFEAHENESHAVRWSPVERMVATGGA------- 346
            |..|.:...:.| |:::.||:....:..::..:.|..|.|..........|.|....|       
Human    67 TDTESSGEDKDS-DSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSS 130

  Fly   347 --DRKVKLWDIGKNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLT 409
              :|.::.|...:.|..||.......| :...:..|:..::....   ||||: |...||:|.|.
Human   131 DDERALEDWVSSETSALPRPRWQALPA-LRERELGSSARFVYEAC---GARVF-VQRFRLQHGLE 190

  Fly   410 GHSGKVMAAKYVQEPIKVVTGSHDRTLKIWD---------------------------------- 440
            ||:|.|....:.|....:.:||.|..:.:||                                  
Human   191 GHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAM 255

  Fly   441 -----------LRSIACIE-----TKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQA 489
                       |.:..|.:     .:..|:|....:..|| ..|.:|...|..:...|:|.::.|
Human   256 CARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDS-PCTFLSAGEDAVVFTIDLRQDRPA 319

  Fly   490 DDVLMPAKITSLDLSKDCNYLI-----------CSVRDDTIKLLDLRK------NQVISTFTNEH 537
            ..::    :|.....|...|.|           ...||..:::.|.||      |.|:..|...|
Human   320 SKLV----VTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQRKIDENENNGVLKKFCPHH 380

  Fly   538 F-------KISC-----DFAR--ASFNSSGLKIACGS-ADGAIYIWNVNGFL-EATLKGHSTAVN 586
            .       .|:|     |...  ||:|...:.:...| :|||.|:....|.. .||:||    ||
Human   381 LVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQYVKRYKGHRNNATVKG----VN 441

  Fly   587 AVSWSPNNNMLAS 599
              .:.|.:..:.|
Human   442 --FYGPKSEFVVS 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg16NP_001138124.2 ATG16 11..197 CDD:285778
SynN 120..229 CDD:294095
WD40 322..605 CDD:238121 77/370 (21%)
WD40 repeat 331..368 CDD:293791 8/45 (18%)
WD40 <341..612 CDD:225201 73/351 (21%)
WD40 repeat 374..410 CDD:293791 10/35 (29%)
WD40 repeat 415..453 CDD:293791 9/87 (10%)
WD40 repeat 461..491 CDD:293791 8/29 (28%)
WD40 repeat 498..536 CDD:293791 12/54 (22%)
WD40 repeat 544..579 CDD:293791 11/38 (29%)
WD40 repeat 585..609 CDD:293791 4/15 (27%)
DCAF8NP_056541.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..147 30/145 (21%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:22500989 39..50 0/10 (0%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:22500989 114..122 2/7 (29%)
WD40 189..506 CDD:392136 56/275 (20%)
WD 1 191..230 10/38 (26%)
WD40 repeat 198..234 CDD:293791 6/35 (17%)
WD 2 234..275 2/40 (5%)
WD40 repeat 240..281 CDD:293791 2/40 (5%)
WD 3 281..321 10/40 (25%)
WD40 repeat 286..327 CDD:293791 10/45 (22%)
WD 4 329..369 8/39 (21%)
WD40 repeat 335..383 CDD:293791 11/47 (23%)
WD 5 385..424 10/38 (26%)
WD40 repeat 390..429 CDD:293791 11/38 (29%)
WD 6 432..472 8/27 (30%)
WD40 repeat 437..474 CDD:293791 6/22 (27%)
WD 7 476..515
WD40 repeat 481..505 CDD:293791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 558..597
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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