DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg16 and atg-16.1

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_508768.2	Gene:	atg-16.1 / 180717	WormBaseID:	WBGene00017178	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	615	Identity:	168/615 - (27%)
Similarity:	289/615 - (46%)	Gaps:	106/615 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WRAHVVRRLRERNRKECDNFKEIIEQNNRLIDHVAQLKADNLKISVENEQLRNAVSTGGTGSNVA 72
            :|..::.||            |.::|.|:   ..|.|..:..|::   |||......|.:.||
Worm     5 YRKLIIERL------------EDVKQRNK---QTATLYNNYSKLA---EQLEKKHKYGTSSSN-- 49

  Fly    73 IATLEK-KLLSQQEELTELHKRKGENSQMIVDLNQKV----EQQRIIISEKEHSLVEQQTNNNRL 132
            .:.||. :|...:||:.||::.|.:|.|.::|.|.::    ::...||:||    :..:.....:
Worm    50 SSQLETGELARVKEEMAELYRSKCQNDQRLIDANHRIADFEKKSSAIIAEK----IALEATAKSI 110

  Fly   133 RAEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERLMQYKSKDADKLN 197
            .|:.......|:.||..|:.:.||..|.....:.|.::::.::::....|.::.:...:..|.||
Worm   111 CAKYAKTEVELQRLKVDNDQLNDERIASNTTVTMLTKQIQDIENDRIHFLNKIRELNEQRVDFLN 175

  Fly   198 EENESIIRKRLPSIFRKRSAKLKRDLEDAVREPSSSSNAASSPGAASLQRNSSPAQFVGGLIGDE 262
            .| .::..||       |:::::..:..||::                             |.|:
Worm   176 AE-VALEEKR-------RNSRIQDMITSAVQD-----------------------------ITDK 203

  Fly   263 DFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRASIDTLKATG--YLGQANPTKILMKFEAH 325
            |                           .::.|..||..|| .:.|  .||.:.|::.....|..
Worm   204 D---------------------------TKLEEMLRAMPDT-NSNGDLLLGDSVPSRAEFVLECE 240

  Fly   326 ENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPR-AVLSGSSAGINSVDFDSTGAYILGTS 389
            |.|.:.|.|...|.. ||||:||.:|:|.:..:....| ..|:||:|....:|::....:.:.:|
Worm   241 EGEVNDVHWLDGETF-ATGGSDRNIKIWKVDGHGGYTRIGTLAGSNAAFTRIDYERDRKHFIASS 304

  Fly   390 NDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACIETKFAGS 454
            ||...|:|.:.::||..||:|||.:|...|:.|.. ..|:||.||.:||||:::..|..:.|..|
Worm   305 NDKNVRIWNLDNSRLLSTLSGHSDQVTCVKFYQSH-SAVSGSADRVIKIWDIQNQRCSRSLFPAS 368

  Fly   455 SCNDLVTTDSLG---STIISGHYDKKIRFWDIRTEKQADDVLMPAKITSLDLSKDCNYLICSVRD 516
            ...|:.|  ::|   |...|||:|||:||:|.|:......|.|..:|||||::.....|:.|.||
Worm   369 KVLDVAT--NMGASPSLFASGHFDKKLRFYDGRSTDPVRTVDMGGRITSLDVTMSGCELLVSTRD 431

  Fly   517 DTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSADGAIYIWNVNGF-LEATLKG 580
            |||.|:|||..|.:..::.|:::.|.|.:|...:|....:|.||::|:|::||.|.. ||..|..
Worm   432 DTISLIDLRTFQTVHCYSAENYRTSSDLSRVVLSSGNEYVAAGSSNGSIFVWNRNSTKLEKQLCS 496

  Fly   581 HS-TAVNAVSWSPNNNMLASVGKNKRCTIY 609
            :| .|:.::||:|....|.|..|.|..|::
Worm   497 NSENAIFSLSWNPTGYGLLSSSKQKFVTLW 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778	41/190 (22%)
		SynN	120..229	CDD:294095	19/108 (18%)
		WD40	322..605	CDD:238121	104/288 (36%)
		WD40 repeat	331..368	CDD:293791	13/37 (35%)
		WD40	<341..612	CDD:225201	100/275 (36%)
		WD40 repeat	374..410	CDD:293791	10/35 (29%)
		WD40 repeat	415..453	CDD:293791	14/37 (38%)
		WD40 repeat	461..491	CDD:293791	13/32 (41%)
		WD40 repeat	498..536	CDD:293791	17/37 (46%)
		WD40 repeat	544..579	CDD:293791	12/35 (34%)
		WD40 repeat	585..609	CDD:293791	8/23 (35%)
atg-16.1	NP_508768.2	ATG16	26..155	CDD:400781	33/137 (24%)
		CwlO1	126..>220	CDD:226400	23/158 (15%)
		WD40	235..527	CDD:238121	106/296 (36%)
		WD40 repeat	246..283	CDD:293791	13/37 (35%)
		WD40 repeat	289..325	CDD:293791	10/35 (29%)
		WD40 repeat	330..365	CDD:293791	13/35 (37%)
		WD40 repeat	371..408	CDD:293791	14/38 (37%)
		WD40 repeat	413..449	CDD:293791	17/35 (49%)
		WD40 repeat	459..495	CDD:293791	12/35 (34%)
		WD40 repeat	502..526	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0288
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I2077
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53779
OrthoDB	1	1.010	-	-		D265783at33208
OrthoFinder	1	1.000	-	-		FOG0004186
OrthoInspector	1	1.000	-	-		otm14345
orthoMCL	1	0.900	-	-		OOG6_103883
Panther	1	1.100	-	-	LDO	PTHR19878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2377
SonicParanoid	1	1.000	-	-		X1444
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.800