DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg16 and snrp-40.2

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_491325.1	Gene:	snrp-40.2 / 172015	WormBaseID:	WBGene00015974	Length:	331	Species:	Caenorhabditis elegans

Alignment Length:	327	Identity:	82/327 - (25%)
Similarity:	144/327 - (44%)	Gaps:	22/327 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 AENSRAS--IDTLKATGYLGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIG 356
            |.|..||  ::..|.|..|  ..||.:|   :.|..|.:..::|.....:|:.|.|:::.||::
Worm     7 ARNQMASQFLELPKRTSSL--MAPTMVL---QGHGGEIYTSQFSSDGSFLASAGYDQQIFLWNV- 65

  Fly   357 KNSTEPRAVLSGSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYV 421
            ....|..|||.|....|..|.|::..::::....|...|||.:...........|:..|.:....
Worm    66 FGECENFAVLKGHKGAIMEVKFNADSSHLVSAGTDKTVRVWDMETGSCIRNFKSHTDIVNSVDVN 130

  Fly   422 QE-PIKVVTGSHDRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWD-IR 484
            :. |..:.:.|.|.|:.:.|:||....: ||........||.:.....:|.|..|.:|:.|| :|
Worm   131 RRGPQMICSASDDGTVMVHDMRSKEAAK-KFICKYQQTAVTFNDAADNVICGGIDNQIKVWDMLR 194

  Fly   485 TEKQADDVLMPAK--ITSLDLSKDCNYLICSVRDDTIKLLDLR----KNQVISTFTNEHFKISCD 543
            .:.:.  ||...:  ||||.:|.:.|:|:.:..|.::...|:|    ..::::.:.........:
Worm   195 NDVRY--VLSGHRDTITSLSVSHNGNFLLSNSMDCSLMSWDIRPFVPAQRLVARYQGASHNFEKN 257

  Fly   544 FARASFNSSGLKIACGSADGAIYIWNVNG-FLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCT 607
            ..:..::.....|..||||..:|:||... .....|.||..:||..:..|...:|.|.|.:|  |
Worm   258 LLKCGWSPRDNYITAGSADRFVYVWNAKSRACVYKLPGHLGSVNCTALHPTQQILLSAGSDK--T 320

  Fly   608 IY 609
            |:
Worm   321 IF 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778
		SynN	120..229	CDD:294095
		WD40	322..605	CDD:238121	69/291 (24%)
		WD40 repeat	331..368	CDD:293791	10/36 (28%)
		WD40	<341..612	CDD:225201	69/278 (25%)
		WD40 repeat	374..410	CDD:293791	6/35 (17%)
		WD40 repeat	415..453	CDD:293791	10/38 (26%)
		WD40 repeat	461..491	CDD:293791	8/30 (27%)
		WD40 repeat	498..536	CDD:293791	10/41 (24%)
		WD40 repeat	544..579	CDD:293791	8/35 (23%)
		WD40 repeat	585..609	CDD:293791	8/23 (35%)
snrp-40.2	NP_491325.1	WD40	31..321	CDD:238121	71/298 (24%)
		WD40 repeat	40..77	CDD:293791	10/37 (27%)
		WD40 repeat	82..118	CDD:293791	7/35 (20%)
		WD40 repeat	125..161	CDD:293791	8/36 (22%)
		WD40 repeat	166..202	CDD:293791	10/37 (27%)
		WD40 repeat	208..248	CDD:293791	10/39 (26%)
		WD40 repeat	258..282	CDD:293791	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910