DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Atg16 and Wdr5

DIOPT Version :9

Sequence 1:NP_001138124.2 Gene:Atg16 / 326115 FlyBaseID:FBgn0039705 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_543124.1 Gene:Wdr5 / 140858 MGIID:2155884 Length:334 Species:Mus musculus


Alignment Length:309 Identity:89/309 - (28%)
Similarity:151/309 - (48%) Gaps:18/309 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   312 QANPTKI----LMKF--EAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLSGSS 370
            |:.||.:    .:||  ..|.....:|::||....:|:..||:.:|:|  |....:....:||..
Mouse    25 QSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHK 87

  Fly   371 AGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRT 435
            .||:.|.:.|....::..|:|...::|.|...:...||.|||..|....:..:...:|:||.|.:
Mouse    88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152

  Fly   436 LKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRT----EKQADDVLMPA 496
            ::|||:::..|::|..|.|.....|..:..||.|:|..||...|.||..:    :...||...| 
Mouse   153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP- 216

  Fly   497 KITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLK-IACGS 560
             ::.:..|.:..|::.:..|:|:||.|..|.:.:.|:|....:..|.|  |:|:.:|.| |..||
Mouse   217 -VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF--ANFSVTGGKWIVSGS 278

  Fly   561 ADGAIYIWNV-NGFLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTI 608
            .|..:||||: ...:...|:||:..|.:.:..|..|::||.......||
Mouse   279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atg16NP_001138124.2 ATG16 11..197 CDD:285778
SynN 120..229 CDD:294095
WD40 322..605 CDD:238121 83/290 (29%)
WD40 repeat 331..368 CDD:293791 9/36 (25%)
WD40 <341..612 CDD:225201 80/274 (29%)
WD40 repeat 374..410 CDD:293791 8/35 (23%)
WD40 repeat 415..453 CDD:293791 10/37 (27%)
WD40 repeat 461..491 CDD:293791 9/33 (27%)
WD40 repeat 498..536 CDD:293791 10/37 (27%)
WD40 repeat 544..579 CDD:293791 13/36 (36%)
WD40 repeat 585..609 CDD:293791 7/24 (29%)
Wdr5NP_543124.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31 3/5 (60%)
WD40 37..331 CDD:238121 86/297 (29%)
WD 1 43..82 10/40 (25%)
WD40 repeat 48..85 CDD:293791 9/38 (24%)
WD 2 85..126 10/40 (25%)
WD40 repeat 91..127 CDD:293791 8/35 (23%)
WD 3 128..168 12/39 (31%)
WD40 repeat 132..168 CDD:293791 10/35 (29%)
WD 4 169..208 12/38 (32%)
WD40 repeat 175..210 CDD:293791 10/34 (29%)
WD 5 212..253 11/42 (26%)
WD40 repeat 217..253 CDD:293791 9/35 (26%)
WD 6 256..296 14/41 (34%)
WD40 repeat 261..298 CDD:293791 14/38 (37%)
WD 7 299..333 9/29 (31%)
WD40 repeat 304..330 CDD:293791 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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