DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg16 and AgaP_AGAP012731

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_307121.4	Gene:	AgaP_AGAP012731 / 1268560	VectorBaseID:	AGAP012731	Length:	347	Species:	Anopheles gambiae

Alignment Length:	297	Identity:	87/297 - (29%)
Similarity:	146/297 - (49%)	Gaps:	14/297 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 MKF--EAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLSGSSAGINSVDFDSTG 382
            :||  ..|.....||::||....:|:..||:.:|:|  |....:....:||...||:.|.:.|..
Mosquito    50 LKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSDS 112

  Fly   383 AYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRTLKIWDLRSIACI 447
            ..::..|:|...::|.:...:...||.||:..|....:..:...:|:||.|.:::|||:|:..|:
Mosquito   113 RLLVTASDDKTLKIWELSSGKCLKTLKGHTNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCL 177

  Fly   448 ETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRT----EKQADDVLMPAKITSLDLSKDCN 508
            :|..|.|.....|..:..||.|:|..||...|.||..:    :...||...|  ::.:..|.:..
Mosquito   178 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP--VSFVKFSPNGK 240

  Fly   509 YLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLK-IACGSADGAIYIWNVNG 572
            |::.:..|:|:||.|..|.:.:.|:|....:..|.|  |:|:.:|.| |..||.|..:||||:..
Mosquito   241 YILAATLDNTLKLWDYSKGKCLKTYTGHRNEKYCIF--ANFSVTGGKWIVSGSEDHMVYIWNLQS 303

  Fly   573 -FLEATLKGHSTAVNAVSWSPNNNMLASVGKNKRCTI 608
             .:..||:||:..|...:..|..|::||.......||
Mosquito   304 KEIVQTLQGHTDTVLCTACHPTENIIASAALENDKTI 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778
		SynN	120..229	CDD:294095
		WD40	322..605	CDD:238121	84/290 (29%)
		WD40 repeat	331..368	CDD:293791	10/36 (28%)
		WD40	<341..612	CDD:225201	80/274 (29%)
		WD40 repeat	374..410	CDD:293791	7/35 (20%)
		WD40 repeat	415..453	CDD:293791	11/37 (30%)
		WD40 repeat	461..491	CDD:293791	9/33 (27%)
		WD40 repeat	498..536	CDD:293791	10/37 (27%)
		WD40 repeat	544..579	CDD:293791	14/36 (39%)
		WD40 repeat	585..609	CDD:293791	7/24 (29%)
AgaP_AGAP012731	XP_307121.4	WD40	<47..347	CDD:225201	87/297 (29%)
		WD40	50..344	CDD:238121	87/297 (29%)
		WD40 repeat	61..98	CDD:293791	10/38 (26%)
		WD40 repeat	104..140	CDD:293791	7/35 (20%)
		WD40 repeat	145..181	CDD:293791	11/35 (31%)
		WD40 repeat	188..223	CDD:293791	10/34 (29%)
		WD40 repeat	230..266	CDD:293791	9/35 (26%)
		WD40 repeat	274..311	CDD:293791	15/38 (39%)
		WD40 repeat	317..343	CDD:293791	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910