DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg16 and atg16l2

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_004919969.2	Gene:	atg16l2 / 100485143	XenbaseID:	XB-GENE-6047387	Length:	594	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	186/633 - (29%)
Similarity:	308/633 - (48%)	Gaps:	82/633 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WRAHVVRRLRERNRKECDNFKEIIEQNNRLIDHVAQLKADNLKISVENEQLRNAVSTGGTGSNVA 72
            |:.|::|:|:.|:|.:...|.::|...|:|::....||.....|..|.....:..:.|..|
Frog    14 WKRHIIRQLKHRDRTQNARFHDVIHSYNKLLEKSTLLKQLTETIQTEPGSRFHDEAPGPPG---- 74

  Fly    73 IATLEKKLLSQQEELTELHKRKGENSQMIVDLNQKVEQQRII-------ISEKEHSLVEQQTNNN 130
                ..:...||:|:.||....|:.:....::..:::.|..:       :::..|:|..|....|
Frog    75 ----VPETDGQQKEMEELDTYNGKLAFEACEMRARIQAQEDVMRIQNTRMADLSHTLESQINQKN 135

  Fly   131 RLRAEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERLMQYKSKDADK 195
            :|..::..:.::..:||:..:.:..:...|:..:.|....|..:.|:       :|:.|:.||:.
Frog   136 QLLDDLAWIVATNADLKEDYDHVHRQKQGLEAEYQSKVVALLAITDD-------IMKRKAADAEN 193

  Fly   196 LNEENESIIRKRLPSIFRKRSAKLKRDL--EDAVREPSSSS----NAASSPGAASLQRNSS---- 250
            .||.|:    :|...::|:...|..|..  .||..|.:.::    .:.|:.|.|::::..|
Frog   194 QNELND----RRKEELWRRHCKKALRKCVSSDAGLEHTQTAGGTETSGSAEGEATVKKTRSQSMI 254

  Fly   251 ---PAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRASIDTLKATGYLGQ 312
               .::|:|.:                      ...:...|..|:        :|..:...:...
Frog   255 SLGTSRFMGTI----------------------RNVLGFSFRKGK--------VDLPREEPWHCS 289

  Fly   313 AN-------PTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLSGSS 370
            .|       |||.|...|.||:|.|||::||..|.||||||||.:|:|::.....:....|.||.
Frog   290 PNVCVLCCVPTKALCNKEVHESEVHAVQFSPNSRTVATGGADRVIKIWNVNHGMLQVCRTLEGSG 354

  Fly   371 AGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSHDRT 435
            .||.|::||.:|..||.:|.|..|.:|. :|.:...:||||:|||.|||:.....:.||.|.|||
Frog   355 GGITSIEFDPSGLQILASSFDGAAHLWK-LDGKAYESLTGHTGKVTAAKFKMSLYRAVTCSLDRT 418

  Fly   436 LKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQADDVLMPAKITS 500
            ::.|||:..|||......|.|:|:|.:|..   :||||:||||||||.|:|....:|.:..||||
Frog   419 IREWDLQKAACIRRISVSSYCSDVVCSDYY---MISGHHDKKIRFWDSRSESCFREVTLEEKITS 480

  Fly   501 LDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSADGAI 565
            |.:.::...|:...|||.:.|.|||.:.|...|..:.||..||:.:|..:..|.....|||||.|
Frog   481 LFMDQEQGQLLSCSRDDALSLFDLRSSNVRQVFRADGFKCGCDWTKAILSPDGSYTLAGSADGTI 545

  Fly   566 YIWNV-NGFLEATLKG-HSTAVNAVSWSPNNNMLASVGKNKRCTIYSE 611
            :|||. .|.||.:|.| |..:||||:||.:.:.:.||.:.|...::|:
Frog   546 FIWNTRTGLLERSLNGQHRASVNAVTWSMSGDYVVSVDRGKMAVVWSD 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778	37/192 (19%)
		SynN	120..229	CDD:294095	24/110 (22%)
		WD40	322..605	CDD:238121	122/284 (43%)
		WD40 repeat	331..368	CDD:293791	16/36 (44%)
		WD40	<341..612	CDD:225201	114/273 (42%)
		WD40 repeat	374..410	CDD:293791	12/35 (34%)
		WD40 repeat	415..453	CDD:293791	16/37 (43%)
		WD40 repeat	461..491	CDD:293791	15/29 (52%)
		WD40 repeat	498..536	CDD:293791	14/37 (38%)
		WD40 repeat	544..579	CDD:293791	14/35 (40%)
		WD40 repeat	585..609	CDD:293791	9/23 (39%)
atg16l2	XP_004919969.2	ATG16	33..195	CDD:400781	32/176 (18%)
		WD40	309..592	CDD:238121	122/286 (43%)
		WD40 repeat	315..352	CDD:293791	16/36 (44%)
		WD40 repeat	358..393	CDD:293791	12/35 (34%)
		WD40 repeat	398..432	CDD:293791	16/33 (48%)
		WD40 repeat	440..473	CDD:293791	17/35 (49%)
		WD40 repeat	478..516	CDD:293791	14/37 (38%)
		WD40 repeat	524..560	CDD:293791	14/35 (40%)
		WD40 repeat	567..591	CDD:293791	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265783at33208
OrthoFinder	1	1.000	-	-		FOG0004186
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19878
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1444
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020