DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg16 and atg16l2

DIOPT Version :9

Sequence 1:	NP_001138124.2	Gene:	Atg16 / 326115	FlyBaseID:	FBgn0039705	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_021321986.1	Gene:	atg16l2 / 100034627	ZFINID:	ZDB-GENE-060503-197	Length:	334	Species:	Danio rerio

Alignment Length:	388	Identity:	87/388 - (22%)
Similarity:	161/388 - (41%)	Gaps:	111/388 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEHVWRAHVVRRLRERNRKECDNFKEIIEQNNRLIDHVAQLKADNLKISVENEQLRNAVSTG--G 66
            :...|:.|::|:|:.|||.:...|::||:..:.|:               |..:.|..::.|  |
Zfish    14 QNETWKRHIIRQLKNRNRTQTSLFQDIIQSYHSLL---------------EKSKQRALITKGILG 63

  Fly    67 TGSNVAIATLEKKLLSQQEELTELHKRKGENSQMIVDLNQKVEQQRIIISEKEHSLVEQQTNNNR 131
            :||..:      .:.|.::.|..|....||.:..:|:|.|:|:.:.:.:.|:.:.|.|.|.:.:.
Zfish    64 SGSRTS------PVPSSEDSLASLKTTTGELAYQVVELQQRVQMKEVTLDEQHNKLFEVQNHLSI 122

  Fly   132 LRAEVQLLHSSLEE-----------LKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERL 185
            :..|    ||.|:|           ||:..:::|::|..::..:.  :|||....     :||.:
Zfish   123 MTLE----HSELQERVTEVQTGNRLLKQKYDSLLEQHQNMEKTYR--QEKLHSAD-----ILENM 176

  Fly   186 MQYKSKDADKLNEENESIIRKRLPSIFRKRSAKLKRDLEDAVREP---SSSSNAASSPGAAS--- 244
            ::.|.:.|.::|..||    ||:    |.|.|.:.::|::|..:.   :..|...|.|..:|
Zfish   177 IRPKQQAAARMNHRNE----KRV----RAREASIHKELQEAANKNVNINEESGNVSPPNPSSPQC 233

  Fly   245 -----LQRNSSPAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRASIDTL 304
                 |:|:..|.                              :.||..|:..|..:.|...:.
Zfish   234 ETAERLERSHGPL------------------------------FRSASATSPRIISSIRGLFER- 267

  Fly   305 KATG----------------YLGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVK 351
            |..|                .|....|||.:...:||:...:|||:|....::||||.||.:|
Zfish   268 KIRGKSVCRSEEDLYIPLGVCLAARVPTKAISSLDAHDLGINAVRFSTSTNLLATGGTDRVIK 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg16	NP_001138124.2	ATG16	11..197	CDD:285778	45/198 (23%)
		SynN	120..229	CDD:294095	29/119 (24%)
		WD40	322..605	CDD:238121	13/30 (43%)
		WD40 repeat	331..368	CDD:293791	11/21 (52%)
		WD40	<341..612	CDD:225201	7/11 (64%)
		WD40 repeat	374..410	CDD:293791
		WD40 repeat	415..453	CDD:293791
		WD40 repeat	461..491	CDD:293791
		WD40 repeat	498..536	CDD:293791
		WD40 repeat	544..579	CDD:293791
		WD40 repeat	585..609	CDD:293791
atg16l2	XP_021321986.1	ATG16	21..188	CDD:312208	45/198 (23%)
atg16l2	XP_021321986.1	WD40	296..330	CDD:197651	13/33 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0288
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265783at33208
OrthoFinder	1	1.000	-	-		FOG0004186
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2377
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850