DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE3 and p4htma

DIOPT Version :9

Sequence 1:	NP_651814.1	Gene:	PH4alphaNE3 / 326114	FlyBaseID:	FBgn0051017	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_001074160.1	Gene:	p4htma / 791209	ZFINID:	ZDB-GENE-070112-2222	Length:	478	Species:	Danio rerio

Alignment Length:	333	Identity:	75/333 - (22%)
Similarity:	118/333 - (35%)	Gaps:	82/333 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 VYEVLGMNRQDVALLQARCLVELDR-RDEAHEVLLDQPD-----LADNSISLLD--QFKANPYEA 253
            ::|:.|.    :::.::..:::|.: :...|..||..||     ..|...||||  |......|.
Zfish   142 LFEIPGF----LSVEESNVVMQLAQLKGLTHSSLLTNPDQEEQLTQDELFSLLDLNQDGLLQREE 202

  Fly   254 IDSSPKLGEGYKRLCRSSFSPNPSKLHCRYNSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKD 318
            |.|.....:|   ...||:  |..|:|....:..|..|.|...|    .:...::.|.......|
Zfish   203 ILSLSHSTDG---SWLSSY--NLRKIHTGLETNPSGVLSLQEFK----RVSGGVLRYSGAAQGLD 258

  Fly   319 IQQLITLAEPLLKPTEMFDDNKNEARSSY-RTPLG---GPLLDSLTQRMRDITGLQ---IRQGNP 376
                              ...|...||:: |..||   ..||.|:..|:..:|.|.   :.....
Zfish   259 ------------------GHTKVRQRSTHTRLYLGEGTHHLLKSVRNRVTRLTRLPSSLVDLSEA 305

  Fly   377 INIIKYGFGAPYTNYYDFFKKR--NS---------ESKGFGDRMATFMFYLNDAPYGGATVFP-- 428
            :.:::|..|.....::|.....  ||         .|.....|..|.:.|||.|..||.|.||
Zfish   306 MEVVRYEQGVFSHAHHDSSPTHPDNSCTHTHLAANTSNQVACRYLTVLLYLNSADSGGETSFPVA 370

  Fly   429 -------------------RLNVKVPAERGKVLFWYNL----NGDTHDMEPTTMHAACPVFHGSK 470
                               :.|:||....|..|.|||.    ||...:::..::|..|.|..|.|
Zfish   371 DNRTYEEEVLGDLSQQYCDKGNLKVKPVAGTALLWYNHLSDGNGWVGELDEFSLHGDCLVTRGFK 435

  Fly   471 WVMTAWIH 478
            |..:.|::
Zfish   436 WTGSVWVN 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528
PH4alphaNE3	NP_651814.1	P4Hc	316..478	CDD:214780	47/204 (23%)
p4htma	NP_001074160.1	2OG-FeII_Oxy	<272..442	CDD:304390	41/169 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583483
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1438683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750