DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE3 and P4htm

DIOPT Version :9

Sequence 1:	NP_651814.1	Gene:	PH4alphaNE3 / 326114	FlyBaseID:	FBgn0051017	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_083220.3	Gene:	P4htm / 74443	MGIID:	1921693	Length:	503	Species:	Mus musculus

Alignment Length:	392	Identity:	84/392 - (21%)
Similarity:	142/392 - (36%)	Gaps:	132/392 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 VRFNSTLPALDCFEVAKMYFKWGYFKQALQWITISKARMKEEYSGVYEVLGMNRQDVALLQARCL 216
            :|..|..|.|  ||:.      |:.......:.|..|:||          |:.|..:
Mouse   136 IRTLSLKPLL--FEIP------GFLSDEECRLIIHLAQMK----------GLQRSQI-------- 174

  Fly   217 VELDRRDEAHEVL-LDQPDLADNSISLLDQFKANPYE--AIDSSPKLGEGYKRLCRSSFSPNPSK 278
            :..:..:||...: :.|.||    ..||||......:  .:.:..:||.|
Mouse   175 LPTEEYEEAMSAMQVSQLDL----FQLLDQNHDGRLQLREVLAQTRLGNG--------------- 220

  Fly   279 LHCRYNSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKDIQQLITLAEPLLKPTEMFDDNK--- 340
               |:         :.|..::|        :|..|..|.|...:::|.|  ....::.|.:|
Mouse   221 ---RW---------MTPENIQE--------MYSAIKADPDGDGVLSLQE--FSNMDLRDFHKYMR 263

  Fly   341 ------NE-ARSSYRTPL-----GGPLLDSLTQRMRDITGLQ---IRQGNPINIIKYGFGAPYTN 390
                  || .|:|:.|.|     ...::.::.||:..:|.|.   :....|:.:::||.|..|..
Mouse   264 SHKAESNELVRNSHHTWLHQGEGAHHVMRAIRQRVLRLTRLSPEIVEFSEPLQVVRYGEGGHYHA 328

  Fly   391 YYD-----------FFKKRNSESKGF--GDRMATFMFYLNDAPYGGATVFP-------------- 428
            :.|           ..|...:||..|  ..|..|.:||||:...||.||||
Mouse   329 HVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQ 393

  Fly   429 -------------RLNVKVPAERGKVLFWYNL----NGDTHDMEPTTMHAACPVFHGSKWVMTAW 476
                         :.|::|..::|..:||||.    .|...:::..::|..|.|..|:||:...|
Mouse   394 DDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGEVDDYSLHGGCLVTRGTKWIANNW 458

  Fly   477 IH 478
            |:
Mouse   459 IN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528
PH4alphaNE3	NP_651814.1	P4Hc	316..478	CDD:214780	53/223 (24%)
P4htm	NP_083220.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..110
		EF-hand_7	193..253	CDD:290234	18/100 (18%)
		EFh	195..253	CDD:298682	16/94 (17%)
		P4Hc	247..459	CDD:214780	50/213 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839373
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1438683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750