Protein Alignment PH4alphaNE3 and P4ha1

DIOPT Version :10

• Sequence 1: NP_651814.1
• Gene: PH4alphaNE3 / 326114
• FlyBaseID: FBgn0051017
• Length: 481
• Species: Drosophila melanogaster
• Sequence 2: NP_742059.2
• Gene: P4ha1 / 64475
• RGDID: 621000
• Length: 534
• Species: Rattus norvegicus
• Alignment Length: 499
• Identity: 148/499 - (29%)
• Similarity: 254/499 - (50%)
• Gaps: 54/499 - (10%)

  Fly    26 DLMQLDVELIDNLMNYAEKIDEKASQLKRLAQELRQPLHSAKGREEEYLGNPLHSFPLIRHMYQD 90
            ||:..:.:|:.:|.:|.:..::|..|:|:.|::|.:...:|....|.::|:|:::|.|::.:..:
  Rat    30 DLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTE 94

  Fly    91 WRYLEEFMKKPVGEEEIQFLRRKLPELPWQVDTEEASVSIFRIAETYGMMPWDMANGLIDNVRFN 155
            |..||..:.|.:.:..|..|..:....|...|...|:.::||:.:||.:....::.|.:..|:..
  Rat    95 WSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVKHK 159

  Fly   156 STLPALDCFEVAKM-YFKWGYF------KQALQWI------TISKARMKEEYSGVYEVLGMNRQD 207
            |.|.|.||||:.|: |.:..|:      :|||..:      |:.|..:.:..|  |.|......|
  Rat   160 SFLTAEDCFELGKVAYTEADYYHTELWMEQALMQLEEGEMSTVDKVSVLDYLS--YAVYQQGDLD 222

  Fly   208 VALLQARCLVELDRRDEA-------HEVLLDQPDLADNSIS--LLDQFKANPYE---AIDSSPKL 260
            .|||..:.|:|||...:.       .|.::.:...|:.|.|  ..|| |..|.:   |:|..|:
  Rat   223 KALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSDQ-KTTPKKKGIAVDYLPE- 285

  Fly   261 GEGYKRLCRS---SFSPNPSK-LHCRY-NSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKDIQ 320
            .:.|:.|||.   ..:|...| |.||| :...:...||||.|.|:...:|.|:.:|||:.|.:|:
  Rat   286 RQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIE 350

  Fly   321 QLITLAEPLLKPTEMFDDNKNE--------ARSSYRTPLGGPLLDSLTQRMRDITGLQIRQGNPI 377
            .:..||:|.|....:.|....:        ::|::.:....|::..:..|::|:|||.:.....:
  Rat   351 IVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEEL 415

  Fly   378 NIIKYGFGAPYTNYYDFFKKRNSES---KGFGDRMATFMFYLNDAPYGGATVFPRLNVKVPAERG 439
            .:..||.|..|..::||.:|...::   .|.|:|:||::||::|...|||||||.:...|..::|
  Rat   416 QVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 480

  Fly   440 KVLFWYNL----NGDTHDMEPTTMHAACPVFHGSKWVMTAWIHE 479
            ..:|||||    .||.     :|.||||||..|:|||...|:||
  Rat   481 TAVFWYNLFASGEGDY-----STRHAACPVLVGNKWVSNKWLHE 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..150	CDD:462433	30/123 (24%)
		P4Hc	316..478	CDD:214780	57/176 (32%)
P4ha1	NP_742059.2	P4Ha_N	24..155	CDD:462433	30/124 (24%)
		TPR	205..238		11/34 (32%)
		P4Hc	345..518	CDD:214780	57/177 (32%)