DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE3 and P4HTM

DIOPT Version :9

Sequence 1:	NP_651814.1	Gene:	PH4alphaNE3 / 326114	FlyBaseID:	FBgn0051017	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	464	Identity:	83/464 - (17%)
Similarity:	139/464 - (29%)	Gaps:	215/464 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 VRFNSTLPALDCFEVAKMYFKWGYFKQALQWITISKARMK----------EEYSGVYEVLGMNRQ 206
            :|..|..|.|  ||:.      |:.......:.|..|:||          |||......:.:::.
Human   135 IRTLSLKPLL--FEIP------GFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQL 191

  Fly   207 DVALLQARCLVELDRRDEAH----EVLLDQPDLADNSISLLDQFKANPYEAIDSSPKLGEGYKRL 267
            |:..|       ||:..:.|    |||                          :..:||.|:
Human   192 DLFRL-------LDQNRDGHLQLREVL--------------------------AQTRLGNGW--- 220

  Fly   268 CRSSFSPNPSKLHCRYNSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKDIQQLITLAEPLLKP 332
                                    .:.|..::|        :|..|..|.|...:::|.|  ...
Human   221 ------------------------WMTPESIQE--------MYAAIKADPDGDGVLSLQE--FSN 251

  Fly   333 TEMFDDNK----NEARSS-----------YRTPLGGPLLDSLTQRMRDITGLQ---IRQGNPINI 379
            .::.|.:|    ::|.||           |:......::.::.||:..:|.|.   :....|:.:
Human   252 MDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQV 316

  Fly   380 IKYGFGAPYTNYYD-----------FFKKRNSESKGF---------------------------- 405
            ::||.|..|..:.|           ..|...:||..|
Human   317 VRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNWGLPSILRPGTPMTQAQP 381

  Fly   406 -----------GDRMA------------------------TFMFYLNDAPYGGATVFP------- 428
                       ||...                        |.:||||:...||.||||
Human   382 CTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNNVTGGGETVFPVADNRTY 446

  Fly   429 --------------------RLNVKVPAERGKVLFWYNL----NGDTHDMEPTTMHAACPVFHGS 469
                                :.|::|..::|..:||||.    .|...|::..::|..|.|..|:
Human   447 DEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGT 511

  Fly   470 KWVMTAWIH 478
            ||:...||:
Human   512 KWIANNWIN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528
PH4alphaNE3	NP_651814.1	P4Hc	316..478	CDD:214780	53/284 (19%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		EF-hand_7	192..252	CDD:290234	19/129 (15%)
		EFh	194..252	CDD:238008	18/127 (14%)
		P4Hc	246..519	CDD:214780	50/274 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1438683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750