Protein Alignment PH4alphaNE3 and P4HA1

DIOPT Version :10

• Sequence 1: NP_651814.1
• Gene: PH4alphaNE3 / 326114
• FlyBaseID: FBgn0051017
• Length: 481
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 143/498 - (28%)
• Similarity: 251/498 - (50%)
• Gaps: 52/498 - (10%)

  Fly    26 DLMQLDVELIDNLMNYAEKIDEKASQLKRLAQELRQPLHSAKGREEEYLGNPLHSFPLIRHMYQD 90
            ||:..:.:|:.:|.:|.:..::|..|:|:.|::|.:...:|....|.::|:|:::|.|::.:..:
Human    30 DLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTE 94

  Fly    91 WRYLEEFMKKPVGEEEIQFLRRKLPELPWQVDTEEASVSIFRIAETYGMMPWDMANGLIDNVRFN 155
            |..||..:.|.:.:..|..|..:....|...|...|:.::.|:.:||.:....::.|.:..|:..
Human    95 WSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHK 159

  Fly   156 STLPALDCFEVAKM-YFKWGYF------KQALQWI------TISKARMKEEYSGVYEVLGMNRQD 207
            |.|.|.||||:.|: |.:..|:      :|||:.:      ||.|..:.:..|  |.|......|
Human   160 SFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLS--YAVYQQGDLD 222

  Fly   208 VALLQARCLVELDRRDEA--------HEVLLDQPDLADNSISLLDQFKANPYE---AIDSSPKLG 261
            .|||..:.|:|||...:.        ..::..:.|:..::.......|..|.:   |:|..|: .
Human   223 KALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPE-R 286

  Fly   262 EGYKRLCRS---SFSP-NPSKLHCRY-NSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKDIQQ 321
            :.|:.|||.   ..:| ...||.||| :...:...||||.|.|:...:|.|:.:|||:.|.:|:.
Human   287 QKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEI 351

  Fly   322 LITLAEPLLKPTEMFDDNKNE--------ARSSYRTPLGGPLLDSLTQRMRDITGLQIRQGNPIN 378
            :..||:|.|....:.|....:        ::|::.:....|::..:..|::|:|||.:.....:.
Human   352 VKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQ 416

  Fly   379 IIKYGFGAPYTNYYDFFKKRNSES---KGFGDRMATFMFYLNDAPYGGATVFPRLNVKVPAERGK 440
            :..||.|..|..::||.:|...::   .|.|:|:||::||::|...|||||||.:...|..::|.
Human   417 VANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGT 481

  Fly   441 VLFWYNL----NGDTHDMEPTTMHAACPVFHGSKWVMTAWIHE 479
            .:|||||    .||.     :|.||||||..|:|||...|:||
Human   482 AVFWYNLFASGEGDY-----STRHAACPVLVGNKWVSNKWLHE 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..150	CDD:462433	29/123 (24%)
		P4Hc	316..478	CDD:214780	57/176 (32%)
P4HA1	NP_000908.2	P4Ha_N	24..155	CDD:462433	29/124 (23%)
		TPR	205..238		11/34 (32%)
		P4Hc	345..518	CDD:214780	57/177 (32%)