DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE3 and CG34041

DIOPT Version :9

Sequence 1:	NP_651814.1	Gene:	PH4alphaNE3 / 326114	FlyBaseID:	FBgn0051017	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_001034077.5	Gene:	CG34041 / 3885583	FlyBaseID:	FBgn0054041	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	71/348 - (20%)
Similarity:	139/348 - (39%)	Gaps:	76/348 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NWESRQEFLDTESAKMDLMQLDVELIDNLMNYAEKIDEKASQLKRLAQELRQPLHSAKGREE-EY 73
            |.|:|...  ::|..::::::...::..|.||...::.|...:.....:| ...|....|:: ..
  Fly   252 NSENRHSL--SKSKVINILKIQENVVKYLENYIYALETKLKTIDEALIDL-ATYHIQFERDKLAI 313

  Fly    74 LGNPLHSFPLIRHMYQDWRYLEEFMKKPVGEEEIQFLRRKLPELPWQVDTEEASVSIFRIAETYG 138
            ..:|:.|:.||.||..||.:.:.|:::..|::|:..|......||.:.|..|....|.::...|.
  Fly   314 ASSPVASYSLIHHMQSDWTHWQLFLQEDPGKDELASLMSIKKYLPTKNDISEVCHGISKMLNAYL 378

  Fly   139 MMPWDMANGLIDNVRFNSTLPAL-------------------DCFEVAKMYFKWGYFKQALQWIT 184
            |...|:|||:|...:......||                   ||..::....:...:.::.:|:.
  Fly   379 MTAQDIANGVILGTQTKYISSALKLEYLYMEIICNRHLMSLRDCVALSDHSMEMKDYNKSKEWLN 443

  Fly   185 ISKARMKEE------------YSGVYEV--------LGMNRQDVALL---QARCLVELDRRDEAH 226
            ::.:.::..            |..:.||        |.:...:.||.   :...|:.:.:|...|
  Fly   444 VAISMLESSAYWDPIVPSADLYLKLAEVYVKQQNWTLALETVEFALKSNPRNAQLIRMQKRLSYH 508

  Fly   227 EVLLDQPDLADNSISLLDQFKANPYEAIDSSPKLG-EGYKRLCRSSFSPNPSKLHCRYNSTTSAF 290
             :||..|                      .||||. |......|.:.|     |:|.|::....|
  Fly   509 -ILLGPP----------------------KSPKLNIENNDYRLRKNGS-----LYCFYDTKIRTF 545

  Fly   291 L-ILAPLKMEEISLEPHIVVYHD 312
            . :|||:|.|.:.::|.:::||:
  Fly   546 YSLLAPIKAEVLFIDPLVILYHE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528	30/124 (24%)
PH4alphaNE3	NP_651814.1	P4Hc	316..478	CDD:214780
CG34041	NP_001034077.5	P4Ha_N	29..138	CDD:285528
		P4Ha_N	260..389	CDD:285528	31/129 (24%)
		TPR repeat	452..491	CDD:276809	6/38 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462003
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840