Protein Alignment PH4alphaNE3 and P4HA3

DIOPT Version :10

• Sequence 1: NP_651814.1
• Gene: PH4alphaNE3 / 326114
• FlyBaseID: FBgn0051017
• Length: 481
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 129/527 - (24%)
• Similarity: 219/527 - (41%)
• Gaps: 124/527 - (23%)

  Fly    53 KRLAQELRQPLHSAKGREEEY-----------------LGNPLHSFPLIRHMYQDWRYLEEFMKK 100
            :||...||:.|...:.|..:.                 :.|||.:|.||:.:..|||.:...::
Human    45 RRLLGLLRRYLRGEEARLRDLTRFYDKVLSLHEDSTTPVANPLLAFTLIKRLQSDWRNVVHSLE- 108

  Fly   101 PVGEEEIQFLR----RKLPELPWQVDTEEASVSIFRIAETYGMMPWDMANGLIDNVRFNS----- 156
              ..|.|:.|:    :...:||...|.|.|:.::.|:.:.|.:....:|.|:...|..::
Human   109 --ASENIRALKDGYEKVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLY 171

  Fly   157 ------TLPALDCFEVAKMYFKWGYFKQALQWITISKARMKEEYSGVYEVLGMNRQDVALLQ--- 212
                  :|...|||:|.|:.:..|.:..|:.|:..:.:..:..| |.::.     :|.|.|:
Human   172 SPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSLFRGSY-GEWKT-----EDEASLEDAL 230

  Fly   213 ------------ARCLVELDRRDEAHEVLLDQPD---LADNSISLLDQFKANP----YEAIDSSP 258
                        ..|.:.|.|     |.||..||   :|.|.:........:|    .||:...|
Human   231 DHLAFAYFRAGNVSCALSLSR-----EFLLYSPDNKRMARNVLKYERLLAESPNHVVAEAVIQRP 290

  Fly   259 KL-----GEGYKRLCRSSFS-PN----PSKLHCRYNSTTSAFLILAPLKMEEISLEPHIVVYHDI 313
            .:     .:.|:.||::..| |.    || |:|.|.:.::|:|:|.|::.|.|.|||:|.:|||.
Human   291 NIPHLQTRDTYEGLCQTLGSQPTLYQIPS-LYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDF 354

  Fly   314 LPDKDIQQLITLAEPLLKPTEMFDDNK------NEARSSYRTPLGGPLLDSLTQRMRDITGLQIR 372
            :.|.:.|::..||||.|:.:.:....|      ..::|::......|.|.:|..|:..:|||.:|
Human   355 VSDSEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVR 419

  Fly   373 --QGNPINIIKYGFGAPYTNYYDFFKKRNS---ESKGFGDRMATFMFYLNDAPYGGATVFPRLNV 432
              ....:.::.||.|..|..::|.....:|   ..|. |:|:||||.||:....||||.|...|:
Human   420 PPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKS-GNRVATFMIYLSSVEAGGATAFIYANL 483

  Fly   433 KVPAERG-------------------KVLFWYNLNG---------DTHDMEPTTMHAACPVFHGS 469
            .||..|.                   .||.|:.::|         |.:..:|     |.|.....
Human   484 SVPVVRHCFGGTCTGVVKGTVTHFMLAVLSWWEISGWPTSGYMSMDRNSADP-----AAPALKTE 543

  Fly   470 KWVMTAW 476
            .....:|
Human   544 LLAERSW 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..150	CDD:462433	27/117 (23%)
		P4Hc	316..478	CDD:214780	50/200 (25%)
P4HA3	NP_001275677.1	P4Ha_N	58..160	CDD:462433	22/104 (21%)
		BepA	<188..289	CDD:443813	22/111 (20%)
		P4Hc	356..>478	CDD:214780	36/122 (30%)