DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE3 and phy-3

DIOPT Version :9

Sequence 1:	NP_651814.1	Gene:	PH4alphaNE3 / 326114	FlyBaseID:	FBgn0051017	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_507251.2	Gene:	phy-3 / 188624	WormBaseID:	WBGene00004026	Length:	318	Species:	Caenorhabditis elegans

Alignment Length:	300	Identity:	75/300 - (25%)
Similarity:	120/300 - (40%)	Gaps:	44/300 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 EVLGMNRQDVALLQARCLVELDRRDEAHEVLLDQPDLADNSISLLDQ--FKANPYEAIDSSPKLG 261
            ::||:    |:||.|..|....|    |..||.|.|..:...:.|.:  :..:..|..|...|..
Worm     8 QILGL----VSLLCATWLYSQCR----HIWLLAQDDFNEQFTNFLGEKWWSTDQLELCDDETKDT 64

  Fly   262 EGYKR--LCRSSFSPNPSKLHCRYNSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKDIQQLIT 324
            :..|.  :|          :...||        :.|:.||.||..|.:|:|.:::..:.....:.
Worm    65 KWQKNDSIC----------ITYVYN--------MLPVDMEIISWAPTLVIYRNLMSPRQTASFLN 111

  Fly   325 LAEPLLKPTEMFDDNKNEARSSYRTPLGG--PLLDS------LTQRMRDITGLQIRQGNPINIIK 381
            ..|......:...|......:::|...|.  |..||      ..|..:.|.||.:......:.:.
Worm   112 FIEQRDLEIQKTSDFGTSIETTHRRANGSFIPPEDSNVTVEIKMQAQKRIPGLNLTVAEHFSALS 176

  Fly   382 YGFGAPYTNYYDFFKKRNSESKGF-----GDRMATFMFYLNDAPYGGATVFPRLNVKVPAERGKV 441
            |..|..|..:||:...|:.:...:     |:|:.|.:|.|..|..||.||||.:...|.|..|..
Worm   177 YLPGGHYAVHYDYLDYRSKQDYDWWMNKTGNRIGTLIFVLKPAEKGGGTVFPSIGSTVRANAGDA 241

  Fly   442 LFWYNLNGDTHDMEPTTMHAACPVFHGSKWVMTAWIHEYD 481
            .||:|...| .:.|..:.|..||::.|.|.:.|.||..|:
Worm   242 FFWFNAQAD-EEKEMLSNHGGCPIYEGRKVIATIWIRAYN 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528
PH4alphaNE3	NP_651814.1	P4Hc	316..478	CDD:214780	44/174 (25%)
phy-3	NP_507251.2	P4Hc	102..277	CDD:214780	44/175 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1438683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780