Protein Alignment PH4alphaNE3 and P4ha1

DIOPT Version :10

• Sequence 1: NP_651814.1
• Gene: PH4alphaNE3 / 326114
• FlyBaseID: FBgn0051017
• Length: 481
• Species: Drosophila melanogaster
• Sequence 2: NP_035160.1
• Gene: P4ha1 / 18451
• MGIID: 97463
• Length: 534
• Species: Mus musculus
• Alignment Length: 502
• Identity: 150/502 - (29%)
• Similarity: 253/502 - (50%)
• Gaps: 60/502 - (11%)

  Fly    26 DLMQLDVELIDNLMNYAEKIDEKASQLKRLAQELRQPLHSAKGREEEYLGNPLHSFPLIRHMYQD 90
            ||:..:.:|:.:|.:|.:..::|..|:|:.|::|.:...:|....|.::|:|:::|.|::.:..:
Mouse    30 DLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTE 94

  Fly    91 WRYLEEFMKKPVGEEEIQFLRRKLPELPWQVDTEEASVSIFRIAETYGMMPWDMANGLIDNVRFN 155
            |..||..:.|.:.:..|..|..:....|...|...|:.::||:.:||.:....::.|.:..|:..
Mouse    95 WSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVQHK 159

  Fly   156 STLPALDCFEVAKM-YFKWGYFKQALQWITISKARMKE-EYSGV----------YEVLGMNRQDV 208
            |.|.|.||||:.|: |.:..|:...| |:..:..:::| |.|.|          |.|......|.
Mouse   160 SFLTAEDCFELGKVAYTEADYYHTEL-WMEQALTQLEEGELSTVDKVSVLDYLSYAVYQQGDLDK 223

  Fly   209 ALLQARCLVELDRRDEA-------HEVLLDQPDLADNSIS--LLDQFKANPYE---AIDSSPKLG 261
            |||..:.|:|||...:.       .|.::.:...|:.|.|  ..|| |..|.:   |:|..|: .
Mouse   224 ALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSDQ-KTAPKKKGIAVDYLPE-R 286

  Fly   262 EGYKRLCRS---SFSPNPSK-LHCRY-NSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKDIQQ 321
            :.|:.|||.   ..:|...| |.||| :...:...||||.|.|:...:|.|:.:|||:.|.:|:.
Mouse   287 QKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEI 351

  Fly   322 LITLAEPLLK------------PTEMFDDNKNEARSSYRTPLGGPLLDSLTQRMRDITGLQIRQG 374
            :..||:|.|:            .|..:..:|:...|.|.    .|::..:..|::|:|||.:...
Mouse   352 VKDLAKPRLRRATISNPVTGALETVHYRISKSAWLSGYE----DPVVSRINMRIQDLTGLDVSTA 412

  Fly   375 NPINIIKYGFGAPYTNYYDFFKKRNSES---KGFGDRMATFMFYLNDAPYGGATVFPRLNVKVPA 436
            ..:.:..||.|..|..::||.:|...::   .|.|:|:||::||::|...|||||||.:...|..
Mouse   413 EELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWP 477

  Fly   437 ERGKVLFWYNL----NGDTHDMEPTTMHAACPVFHGSKWVMTAWIHE 479
            ::|..:|||||    .||.     :|.||||||..|:|||...|:||
Mouse   478 KKGTAVFWYNLFASGEGDY-----STRHAACPVLVGNKWVSNKWLHE 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..150	CDD:462433	30/123 (24%)
		P4Hc	316..478	CDD:214780	59/180 (33%)
P4ha1	NP_035160.1	P4Ha_N	24..155	CDD:462433	30/124 (24%)
		TPR	205..238		10/32 (31%)
		P4Hc	345..518	CDD:214780	59/181 (33%)