DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE3 and p4ha3

DIOPT Version :9

Sequence 1:	NP_651814.1	Gene:	PH4alphaNE3 / 326114	FlyBaseID:	FBgn0051017	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	XP_031752143.1	Gene:	p4ha3 / 100495824	XenbaseID:	XB-GENE-962355	Length:	547	Species:	Xenopus tropicalis

Alignment Length:	540	Identity:	133/540 - (24%)
Similarity:	232/540 - (42%)	Gaps:	92/540 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 STLNW-ESRQEFLDTESAKMDLMQLDVELIDNLMNYAEKIDEKASQLKRLAQELRQPLHSAKGRE 70
            |.|:| .:..:...:.::....:.::..|:.:|..|.::..::.|.|:|..::: |..|.|.|..
Frog    20 SWLHWLHAGADMYSSMASIQQAVGMEGALLQHLGQYLQQETQRLSDLRRFYEKV-QASHQAGGPP 83

  Fly    71 EEYLGNPLHSFPLIRHMYQDWRYLEEFMKKPVGEEEIQFLR----RKLPELPWQVDTEEASVSIF 131
            .:   :|:.::.|::.:..:|.   ..:......|.||.|:    :...:||...|.|.|:.::.
Frog    84 VQ---DPILAYTLLKRLQSEWM---NVVHSSEANENIQALKEGYEKVKQDLPAPEDVEGAAKALM 142

  Fly   132 RIAETYGMMPWDMANG-----------LIDNVRFNSTLPALDCFEVAKMYFKWGYFKQALQWITI 185
            |:.:.|.:....:|.|           |:.|....|.:.|.|||.:.|:.:....:..::.|:..
Frog   143 RLQDVYSLNVNGLARGMFQRSSSSDTKLLYNPPHLSIMSADDCFHIGKVAYDMEDYYHSIPWLEE 207

  Fly   186 SKARMKEEYSGVYEVLGMNRQDVALLQARCLVELD--------------RRDEAHEVLLDQPD-- 234
            :.:|.:..|.      ....:|...|:.    .||              ..|.:.|.||..||
Frog   208 AVSRFRGSYG------NWRTEDEGSLEE----ALDYLAFSYYKAGNISHALDLSRECLLYDPDNG 262

  Fly   235 -LADNSISLLDQFKANPYEAIDSSP-----------KLGEGYKRLCRSSFSPNPS----KLHCRY 283
             ||.|..........:|....|:..           |..:.|:.||::..|...|    .:.|.|
Frog   263 RLARNIAKYEQILYESPTADADAEEMKLQRPNVTHLKTRDLYEGLCQTLGSQPTSYEDPHMSCMY 327

  Fly   284 NSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKDIQQLITLAEPLLKPTEMFDDNKNEARSSYR 348
            ::.:..:|:|.|:|.|.:||.|.:|:|||.:.|.:.:::..||.|.|..:.:....| :|.:.||
Frog   328 DTNSHPYLLLQPMKKEIVSLRPQVVLYHDFVSDLEAEKIKELASPWLHRSVVASGEK-QAEAEYR 391

  Fly   349 TPLGG-------PLLDSLTQRMRDITGLQIRQGNP-----INIIKYGFGAPYTNYYDFFKKRNSE 401
            .....       |.:.:|..|:..:|||   ..:|     :.::.||.|..|..::|....|.|.
Frog   392 ISKSAWLKDTIHPFVQNLDTRISAVTGL---NAHPPYAEYLQVVNYGIGGHYEPHFDHATSRKSP 453

  Fly   402 --SKGFGDRMATFMFYLNDAPYGGATVFPRLNVKVPAERGKVLFWYNLN----GDTHDMEPTTMH 460
              ....|:|:||||.||:....||:|.|...|...|..:...:||:||:    ||     ..|:|
Frog   454 LYRTNTGNRLATFMIYLSHVDLGGSTAFVFANFSSPVVKNAAVFWWNLHRNGLGD-----EDTLH 513

  Fly   461 AACPVFHGSKWVMTAWIHEY 480
            |.|||..|||||...||||:
Frog   514 AGCPVIIGSKWVANKWIHEF 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528	26/138 (19%)
PH4alphaNE3	NP_651814.1	P4Hc	316..478	CDD:214780	55/179 (31%)
p4ha3	XP_031752143.1	P4Ha_N	35..>104	CDD:400573	13/75 (17%)
		TPR repeat	182..210	CDD:276809	6/27 (22%)
		TPR repeat	215..257	CDD:276809	8/51 (16%)
		P4Hc	359..531	CDD:214780	55/180 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000