Protein Alignment PH4alphaNE3 and p4ha1b

DIOPT Version :9

• Sequence 1: NP_651814.1
• Gene: PH4alphaNE3 / 326114
• FlyBaseID: FBgn0051017
• Length: 481
• Species: Drosophila melanogaster
• Sequence 2: NP_999856.1
• Gene: p4ha1b / 100003675
• ZFINID: ZDB-GENE-030131-4089
• Length: 536
• Species: Danio rerio
• Alignment Length: 524
• Identity: 146/524 - (27%)
• Similarity: 251/524 - (47%)
• Gaps: 76/524 - (14%)

  Fly    13 SRQEFLDTESAKMDLMQLDVELIDNLMNYAEKIDEKASQLKRLAQELRQPLHSAKGREEEYLGNP 77
            :..:|..:.....||:..:.:|:.:|..|.::.:.:..|:|..|.:|.....:|....|.:||:|
Zfish    17 AHNDFFTSTGQMTDLLYAEKDLVTSLKEYIKQEENRLEQVKEWADKLDSLTITATQDPEGFLGHP 81

  Fly    78 LHSFPLIRHMYQDWRYLEEFMKKPVGEEEIQFLRRKLPELPWQVDTEEASVSIFRIAETYGMMPW 142
            :::|.|::.:..:|..||..:.|......|..|..:....|...|...|:.::.|:.:||.:...
Zfish    82 VNAFKLMKRLNSEWSDLENLVLKDTTNGFISNLTVQRQYFPTDEDQTGAAKALLRLQDTYQLSAN 146

  Fly   143 DMANGLIDNVRFNSTLPALDCFEVAKM-YFKWGYFKQALQWITISKARMKE-EYSGVYEVLGMNR 205
            .:::|.:..|...|.:...||:|:.|: |....|:...| |:..:.:::.| |.|.:.:|..|:.
Zfish   147 AISSGDLPGVVHKSRMTVEDCYELGKIAYSDADYYHTEL-WMAQALSQLDEGEESPIDKVTVMDY 210

  Fly   206 QDVALLQARCL---VELDRR----DEAH----------EVLLDQPDLADNSIS------LLDQFK 247
            ...|:.|...|   :||.:|    |..|          |..|::...|:|...      :||:..
Zfish   211 LSYAIYQQGELDRALELTKRMLKLDPNHHRANGNLKYFEFQLEKQRKAENEKKEEDQKRVLDKRD 275

  Fly   248 ANPYEAIDSSPKLGEGYKRLCRS---SFSP-NPSKLHCRY-NSTTSAFLILAPLKMEEISLEPHI 307
            |....:.|..|: .:.|:||||.   ..:| ..|:|.||| |:..:..|:|||:|.|:....|.|
Zfish   276 AQRKRSKDPLPE-RKKYERLCRGEGIKLTPRRQSRLFCRYSNNNRNPRLLLAPVKQEDEWDRPRI 339

  Fly   308 VVYHDILPDKDIQQLITLAEPLLKPTEMFDDNKNEARSSYRTPLGGPL----------------- 355
            |.||:|:.|.:|:.:..:|:|.|:            |::...|:.|.|
Zfish   340 VRYHEIISDSEIETVKEMAKPRLR------------RATISNPITGVLETAPYRISKSAWLSGYE 392

  Fly   356 ---LDSLTQRMRDITGLQIRQGNPINIIKYGFGAPYTNYYDFFKKRNSES---KGFGDRMATFMF 414
               ::.:.||:.|:|||::.....:.:..||.|..|..::||.:|...::   .|.|:|:||::|
Zfish   393 HSTIERINQRIEDVTGLEMDTAEELQVANYGVGGQYEPHFDFGRKDEPDAFKELGTGNRIATWLF 457

  Fly   415 YLNDAPYGGATVFPRLNVKVPAERGKVLFWYNL----NGDTHDMEPTTMHAACPVFHGSKWVMTA 475
            |::|...||||||..:...|..::|..:|||||    .||.     :|.||||||..|:|||...
Zfish   458 YMSDVSAGGATVFTDVGAAVWPKKGTAVFWYNLFPSGEGDY-----STRHAACPVLVGNKWVSNK 517

  Fly   476 WIHE 479
            ||||
Zfish   518 WIHE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528	29/123 (24%)
		P4Hc	316..478	CDD:214780	57/188 (30%)
p4ha1b	NP_999856.1	P4Ha_N	24..153	CDD:285528	29/128 (23%)
		TPR repeat	164..199	CDD:276809	9/35 (26%)
		TPR_16	168..238	CDD:290168	18/70 (26%)
		TPR repeat	204..234	CDD:276809	8/29 (28%)
		P4Hc	347..520	CDD:214780	57/189 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920