DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31016 and CG34345

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	157/534 - (29%)
Similarity:	255/534 - (47%)	Gaps:	69/534 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVLSWI----------AEGYRDRQNYVI---SVEEKMDLLEKDRELIIVLDSYATELNEKIIMLK 64
            ::|:||          .:...|....||   |:....:|.|.:...:..|::|.:.|.:||..|:
  Fly     9 ILLNWILLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLR 73

  Fly    65 RIVKEFKQPLEKAKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVE--KMRED 127
            ..:..........|....:|:|||::|..|:|:.|:||.|:...||.. |..|:.:.|  |:...
  Fly    74 IFINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKDQ-GNIKVDIEEMNKLINR 137

  Fly   128 LPVENDLMEANQAMFRILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASK 192
            .|..||:.||...|.||.|.|||:..|::.|.:.|.|...:||||||..:..:.:....::.|::
  Fly   138 TPHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAE 202

  Fly   193 WLSAAKDLLVDQPR-----KYHEVMGITKADVTLLLARSLIASGNVSIATDMLMRDFMFGEAGSA 252
            |...|..:.. :|:     |::   ...:.::..:...|.:..|:|...||.|..
  Fly   203 WYRIALSVFT-KPKNNIAFKFY---APKRKELEKMFVISRLQEGSVENLTDCLKE---------- 253

  Fly   253 LTVHFLRNKPKPS-INLESWESDESFNQLCRSSSRRQMGESKPS-RLHCRYNTITTPFLKLAPFR 315
                 |...|..| ::|...:|.....|.|:       |:..|. :|.||||:.||||:::||.:
  Fly   254 -----LSQDPNNSLVHLRPRKSPTMIEQGCQ-------GKFPPGPQLVCRYNSTTTPFMRIAPLK 306

  Fly   316 MEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVE----KGSDEIDPSRSADGAWLPH 376
            .||:|.||.:..||:|:.|:||.:|          ..|.|.|    ..::...|.|...   |.|
  Fly   307 EEEISRDPLIWLYHDVIYDSEIAQL----------TNVTREEMILGTTTNYTTPDRVNR---LFH 358

  Fly   377 QNIDPDDLEVLNR-IGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNSKTF-SLETVGDR 439
            ..:..||...|:: :..|:.|::||:..:.:.:..:.||.||:|..|.||.:.|.: .|...|||
  Fly   359 IKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDYMDIKLYPELTEEGDR 423

  Fly   440 IATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFHGACPLISGTKLVM 504
            :.|.|||:.:|..||.|:||...||:..:|||||||:|:.... |.:..|.|..||.|.|::.|:
  Fly   424 LMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNG-DPNLLTRHAVCPTIVGSRWVL 487

  Fly   505 TRWIYELDQMFLIP 518
            .:.:...:|||..|
  Fly   488 VKSMLNYEQMFKKP 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	41/130 (32%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	59/180 (33%)
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	41/130 (32%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	59/178 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461908
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910